SHP2-IN-44
SHP2-IN-44 (Compound 26) is an allosteric and orally active SHP2 inhibitor with an IC50 of 27 ?nM. SHP2-IN-44 also inhibits ERK phosphorylation (IC50 of 299 ?nM) without off-target hERG activity. SHP2-IN-44 has a broad-spectrum anticancer activity, such as juvenile myelomonocytic leukemia, neuroblastoma and breast cancer. SHP2-IN-44 can be used for Noonan syndrome, LEOPARD syndrome and cancers research.
For research use only. We do not sell to patients.
- CAS No.: 2818955-47-2
- Formula: C22H23ClFN7S
- Molecular Weight:471.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2818955-47-2
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Molecular Weight 471.98
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Formula C22H23ClFN7S
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SMILES
NC[C@@]1(C2=C(C=CC=C2)F)[C@]3([H])[C@@]1([H])CCN(C4=NC(N)=C(N=C4)SC5=CC=NC(N)=C5Cl)C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SHP2-IN-44 Related Classifications
HY-175803 Related Classifications
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