2818955-47-2
Chemical Structure
SHP2-IN-44
- CAS No.: 2818955-47-2
- Formula:C22H23ClFN7S
- Molecular Weight:471.98
IUPAC Name: 3-((2-amino-3-chloropyridin-4-yl)thio)-6-((1S,6R,7R)-7-(aminomethyl)-7-(2-fluorophenyl)-3-azabicyclo[4.1.0]heptan-3-yl)pyrazin-2-amine
InChIKey: YDRLWYMRXFMAPX-UZRORNOBSA-N
SMILES: NC[C@@]1(C2=C(C=CC=C2)F)[C@]3([H])[C@@]1([H])CCN(C4=NC(N)=C(N=C4)SC5=CC=NC(N)=C5Cl)C3
Biological Activity: SHP2-IN-44 (Compound 26) is an allosteric and orally active SHP2 inhibitor with an IC50 of 27 ?nM. SHP2-IN-44 also inhibits ERK phosphorylation (IC50 of 299 ?nM) without off-target hERG activity. SHP2-IN-44 has a broad-spectrum anticancer activity, such as juvenile myelomonocytic leukemia, neuroblastoma and breast cancer. SHP2-IN-44 can be used for Noonan syndrome, LEOPARD syndrome and cancers research[1].
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SHP2-IN-44 | SHP2-IN-44 (Compound 26) is an allosteric and orally active SHP2 inhibitor with an IC50 of 27 ?nM. SHP2-IN-44 also inhibits ERK phosphorylation (IC50 of 299 ?nM) without off-target hERG activity. SHP2-IN-44 has a broad-spectrum anticancer activity, such as juvenile myelomonocytic leukemia, neuroblastoma and breast cancer. SHP2-IN-44 can be used for Noonan syndrome, LEOPARD syndrome and cancers research. | |||||||||||||||||||||
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