2,7-Dimethylnaphthalene
Based on 1 Customer Validation
2,7-Dimethylnaphthalene is an inhibitor of CYP1A2 and CYP2A5, with an IC50 of 65 μM against CYP1A2. 2,7-Dimethylnaphthalene does not alter the levels of nicotine and its metabolites in mouse urine.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 582-16-1
- Formula: C12H12
- Molecular Weight:156.23
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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CYP1A2 65 μM (IC50) |
CYP2A5 |
2,7-Dimethylnaphthalene (pre-incubated at 37 °C for 10 min; incubated for 20 min) inhibits recombinant CYP1A2 expressed by baculovirus-insect cells, with an IC50 of 65 µM[1].
2,7-dimethylnaphthalene acts as a potent CYP2A5 inhibitor[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD2F1 (female, 7 weeks old, 17-23 g)[2]
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Dosage:2 mg/kg
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Administration:p.o.; single dose
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Result:Showed no effect on urinary excretion levels of nicotine, cotinine, cotinine N-oxide, trans-3-hydroxycotinine, or nicotine 1-N-oxide compared to control mice.
Maintained the yield of nicotine and its four measured metabolites in urine at ~58% of the administered nicotine dose, matching control levels.
Chemical Information
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CAS No. 582-16-1
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Appearance Solid
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Molecular Weight 156.23
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Formula C12H12
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Color Off-white to light yellow
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SMILES
C=1C=C(C=C2C=C(C=CC12)C)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 10 mg/mL (64.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1 mg/mL (6.40 mM); Clear solution
This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4008 mL | 32.0041 mL | 64.0082 mL | 160.0205 mL |
| 5 mM | 1.2802 mL | 6.4008 mL | 12.8016 mL | 32.0041 mL | |
| 10 mM | 0.6401 mL | 3.2004 mL | 6.4008 mL | 16.0020 mL | |
| 15 mM | 0.4267 mL | 2.1336 mL | 4.2672 mL | 10.6680 mL | |
| 20 mM | 0.3200 mL | 1.6002 mL | 3.2004 mL | 8.0010 mL | |
| 25 mM | 0.2560 mL | 1.2802 mL | 2.5603 mL | 6.4008 mL | |
| 30 mM | 0.2134 mL | 1.0668 mL | 2.1336 mL | 5.3340 mL | |
| 40 mM | 0.1600 mL | 0.8001 mL | 1.6002 mL | 4.0005 mL | |
| 50 mM | 0.1280 mL | 0.6401 mL | 1.2802 mL | 3.2004 mL | |
| 60 mM | 0.1067 mL | 0.5334 mL | 1.0668 mL | 2.6670 mL |
2,7-Dimethylnaphthalene Related Classifications
HY-W045990 Related Classifications
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