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Tyroserleutide hydrochloride 

Cat. No.: HY-106263B Purity: 99.47%
Handling Instructions

Tyroserleutide hydrochloride, isolated from the degradation products of porcine spleen, is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Tyroserleutide hydrochloride Chemical Structure

Tyroserleutide hydrochloride Chemical Structure

CAS No. : 852982-42-4

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5 mg USD 230 In-stock
Estimated Time of Arrival: December 31
10 mg USD 400 In-stock
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25 mg USD 750 In-stock
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50 mg USD 1150 In-stock
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100 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Tyroserleutide hydrochloride, isolated from the degradation products of porcine spleen[1], is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo[2].

IC50 & Target

Antitumor tripeptide[1][2]

In Vitro

Tyroserleutide (YSL) exhibits immuno-modulating effects, such as enhancing concanavalin (ConA) induced proliferation of mouse spleen lymphocytes, phagocytosis of mouse peritoneal macrophages, and the activity of natural killer (NK) cells[1].
Tyroserleutide (YSL), an immunologically therapeutic tripeptide, can promote hepatocarcinoma cell (H22) apoptosis through downregulating Bcl-2 and cyclin D1 expression[2].
Tyroserleutide is an ideal choice for inducing apoptosis of liver tumor cells[2].
Tyroserleutide inhibits tumor growth and does not cause severe toxicities in the major organs. Tyroserleutide can inhibit tumor cell migration[2].

In Vivo

Tyroserleutide (10-80 μg/kg; injection (i.p.) one time every day until mice are dead) displays obvious anti-tumor activity. Tyroserleutide significantly prolongs the survival time of the murine H22 implanted mice[1].

Animal Model: Female Kun-Ming mice (18-22 g, 6 week old) with H22 tumor model[1]
Dosage: 10, 20, 40, and 80 μg/kg
Administration: Injection (i.p.) one time every day until mice were dead.
Result: Survival times are 25.53±14.14, 25.82±14.29, 30.47±17.89, 35.06±20.90 days for 10, 20, 40, and 80 μg/kg, respectively.
Clinical Trial
Molecular Weight

417.88

Formula

C₁₈H₂₈ClN₃O₆

CAS No.

852982-42-4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (598.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3930 mL 11.9652 mL 23.9303 mL
5 mM 0.4786 mL 2.3930 mL 4.7861 mL
10 mM 0.2393 mL 1.1965 mL 2.3930 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TyroserleutideOthersYSLtripeptidetumorAntitumorInhibitorinhibitorinhibit

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Product name:
Tyroserleutide hydrochloride
Cat. No.:
HY-106263B
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