Studies on the large scale synthesis and anti-tumor activity of YSL

  • Prep Biochem Biotechnol. 2003 Aug;33(3):189-95. doi: 10.1081/PB-120022987.
Chao Wang  1 ,  Wenfeng Ding ,  Ming Zhao ,  Gang Lin ,  Shiqi Peng
Affiliations
  • 1. College of Pharmaceutical Sciences, Peking University, Beijing, P.R. China.
PMID: 12916810 DOI: 10.1081/PB-120022987
Abstract

H-Tyr-Ser-Leu-OH (YSL), isolated from the degradation products of porcine spleen, was synthesized by a solution method on a large scale via two synthetic strategies. Its structure was confirmed by spectroscopic and related analyses. The in vivo anti-tumor activity was evaluated with murine H22 tumor models. The result indicated that, with the administration of YSL, the survival time of the murine H22 implanted mice was significantly prolonged.

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