Sodium tetradecyl sulfate (27% in water)
Based on 1 Customer Validation
Sodium tetradecyl sulfate (Tergitol 4) is a novel scleroembolic agent and an apoptosis inducer. Sodium tetradecyl sulfate can be used for research on varicose veins and vascular malformation diseases.
For research use only. We do not sell to patients.
- Purity: 99.54%
- CAS No.: 139-88-8
- Formula: C14H29NaO4S
- Molecular Weight:316.43
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Sodium tetradecyl sulfate induces endothelial activation and release of endothelial particles in human umbilical vein endothelial cells (HUVEC)[1]. Sodium tetradecyl sulfate can increase the expression of activation markers CD54 and CD62e in human umbilical vein endothelial cells (HUVEC), promoting HUVEC cell activation[1]. Sodium tetradecyl sulfate inhibits proliferation and induces apoptosis in mouse endothelial tumor (EOMA) cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:A bilateral iliac EVAR model with a type I endoleak[2].
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Dosage:5 mL Chitosan–Sodium Tetradecyl Sulfate Hydrogel (CH–STS)
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Administration:Intratumoral injection
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Result:Reduced internal leakage and tended to adhere to SG rather than arterial wall.
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Animal Model:Male and female Sprague-Dawley rats, weighing 310 ± 24 g [3].
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Dosage:0.3 mL 1% STS
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Administration:Intravenous injection (i.v.); once daily; 30 days
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Result:Produced a solid occlusion of the vein in a significant number of cases.
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Animal Model:Rat[5].
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Dosage:0.2 mL of liquid STS 1% or 0.2 mL STS 1% sclerosing foam
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Administration:Intravenous injection (i.v.)
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Result:Increased ET-1 levels at 1 minute and 5 minutes.
Chemical Information
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CAS No. 139-88-8
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Appearance Liquid (Density: 1.06 g/cm3)
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Molecular Weight 316.43
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Formula C14H29NaO4S
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Color Colorless to light yellow
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SMILES
O=S(OC(CC(C)C)CCC(CCCC)CC)(O[Na])=O
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Synonyms
Tergitol 4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 62.5 mg/mL (197.52 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Korean - KR (477 KB)
- Portuguese - PT (477 KB)
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Handling Instructions (2659 KB)
References
[1]. Connor DE, et al. Sirolimus and propranolol inhibit endothelial proliferation while detergent sclerosants induce endothelial activation, microparticle release and apoptosis in vitro. Phlebology. 2020 Sep;35(8):566-575. [Content Brief]
[2]. Zehtabi F, et al. Chitosan-Sodium Tetradecyl Sulfate Hydrogel: Characterization and Preclinical Evaluation of a Novel Sclerosing Embolizing Agent for the Treatment of Endoleaks. Cardiovasc Intervent Radiol. 2017 Apr;40(4):576-584. [Content Brief]
[3]. Morsiani E, et al. Effect of intravenous and intraperivenous injections of sclerosants (sodium tetradecyl sulfate and hydroxy polyethoxy dodecan) on the rat femoral vein. Res Exp Med (Berl). 1987;187(6):439-49. [Content Brief]
[4]. Zimmet SE. The prevention of cutaneous necrosis following extravasation of hypertonic saline and sodium tetradecyl sulfate. J Dermatol Surg Oncol. 1993 Jul;19(7):641-6. [Content Brief]
[5]. Frullini A, et al. Significant endothelin release in patients treated with foam sclerotherapy. Dermatol Surg. 2012 May;38(5):741-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.1603 mL | 15.8013 mL | 31.6026 mL | 79.0064 mL |
| 5 mM | 0.6321 mL | 3.1603 mL | 6.3205 mL | 15.8013 mL | |
| 10 mM | 0.3160 mL | 1.5801 mL | 3.1603 mL | 7.9006 mL | |
| 15 mM | 0.2107 mL | 1.0534 mL | 2.1068 mL | 5.2671 mL | |
| 20 mM | 0.1580 mL | 0.7901 mL | 1.5801 mL | 3.9503 mL | |
| 25 mM | 0.1264 mL | 0.6321 mL | 1.2641 mL | 3.1603 mL | |
| 30 mM | 0.1053 mL | 0.5267 mL | 1.0534 mL | 2.6335 mL | |
| 40 mM | 0.0790 mL | 0.3950 mL | 0.7901 mL | 1.9752 mL | |
| 50 mM | 0.0632 mL | 0.3160 mL | 0.6321 mL | 1.5801 mL | |
| 60 mM | 0.0527 mL | 0.2634 mL | 0.5267 mL | 1.3168 mL | |
| 80 mM | 0.0395 mL | 0.1975 mL | 0.3950 mL | 0.9876 mL | |
| 100 mM | 0.0316 mL | 0.1580 mL | 0.3160 mL | 0.7901 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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