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Cat. No.: HY-158706

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SAE-IN-2

SAE-IN-2 (compound 6) is a potent inhibitor of sumo activating enzume (SAE), with the IC₅₀ of 27.8 nM.

For research use only. We do not sell to patients.

Formula: C₂₇H₃₀ClN₅O₅S₂
Molecular Weight:604.14

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SAE-IN-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

SAE-IN-2 (compound 6) is a potent inhibitor of sumo activating enzume (SAE), with the IC₅₀ of 27.8 nM^[1].

Chemical Information

Molecular Weight 604.14
Formula C₂₇H₃₀ClN₅O₅S₂
SMILES

O[C@@H]1[C@@H](COS(=O)(N)=O)C[C@@H](NC2=NC=NC=C2C(C3=CC([C@@]4(CCC5)C6=C(CCN4)C=CC(Cl)=C6)=C5S3)=O)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wigen Biomedicine Technology (Shanghai) Co., Ltd. Preparation of the aryl compounds and their application as anticancer agents. World Intellectual Property Organization, WO2024067676 A1 2024-04-04

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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