country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-179060

Copy Link Print Information

LAG-3 PROTAC-1

LAG-3 PROTAC-1 is a lymphocyte activation gene-3 (LAG-3) PROTAC degrader with a DC₅₀ of 0.27 μM. LAG-3 PROTAC-1 induces the formation of a ternary complex with LAG-3 and CRL4^CRBN, promoting proteasomal degradation. LAG-3 PROTAC-1 is applicable for cancer-related research.
(Pink: LAG-3 ligand (HY-179061); Blue: Cereblon ligand (HY-10984); Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₄H₃₆N₆O₅
Molecular Weight:608.69

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

LAG-3 PROTAC-1 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

LAG-3 PROTAC-1 is a lymphocyte activation gene-3 (LAG-3) PROTAC degrader with a DC₅₀ of 0.27 μM. LAG-3 PROTAC-1 induces the formation of a ternary complex with LAG-3 and CRL4^CRBN, promoting proteasomal degradation. LAG-3 PROTAC-1 is applicable for cancer-related research^[1]. (Pink: LAG-3 ligand (HY-179061); Blue: Cereblon ligand (HY-10984); Black: linker).

IC₅₀ & Target

Cereblon

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

LAG-3 PROTAC-1 (0.001-10 μM; 24 h) potently and selectively induces dose-dependent degradation of LAG-3 in Raji-LAG3 cells with a DC₅₀ of 0.27 μM^[1].
LAG-3 PROTAC-1 forms a stable, conformationally favorable complex with purified LAG-3, as demonstrated by 100 ns MD simulations, with key binding interactions that support ternary complex formation with CRL4_CRBN^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Raji-LAG3 cells (LAG-3-expressing Raji cells)
Concentration:

0.001, 0.01, 0.1, 1, 10 μM
Incubation Time:

24 h
Result:

Induced potent, dose-dependent degradation of LAG-3 protein levels, with a maximum reduction of up to 85% at 10 μM.
Confirmed degradation to be CRL4CRBN-dependent, as co-treatment with the NAE inhibitor MLN4924 rescued LAG-3 levels.
Showed no degradation in Raji-Null cells lacking LAG-3, confirming target specificity.
Achieved a DC₅₀ of 0.27 μM.

Chemical Information

Molecular Weight 608.69
Formel C₃₄H₃₆N₆O₅
SMILES

O=C(NCCCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)[C@H]([C@@H](C4=CC=CC=C4)C5)CN5CC6=CC=CC=N6
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Vázquez NG, et al. Design and validation of the first-in-class PROTACs for targeted degradation of the immune checkpoint LAG-3. Bioorganic & medicinal chemistry letters. 2026 Jan 01;130:130428. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

LAG-3 PROTAC-1

Alle PROTACs Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

LAG-3 PROTAC-1 Related Classifications

HY-179060 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target