GLS1 Inhibitor-1
Based on 1 Customer Validation
GLS1 Inhibitor-1 (Compound 27) is an orally active inhibitor for glutaminase 1 (GLS1) with an IC50 of 0.021 μM. GLS1 Inhibitor-1 inhibits the proliferation of PC-3 with an IC50 of 0.3 nM. GLS1 Inhibitor-1 exhibits antitumor efficacy against NCI-H1703 with GI50 of 0.011 μM. GLS1 Inhibitor-1 exhibits moderate pharmacokinetic characteristics.
For research use only. We do not sell to patients.
- Purity: 98.5%
- CAS No.: 1832646-52-2
- Formula: C19H21N7O2S
- Molecular Weight:411.48
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Orally Active Compound Library
HY-L061
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Glutamine Metabolism Compound Library
HY-L064
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Anti-Cancer Metabolism Compound Library
HY-L083
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Mitochondria-Targeted Compound Library
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Cuproptosis Compound Library
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Metabolic Enzyme Compound Library
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MCE Bioactive Compound Library
HY-L001V
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Amino Acid Metabolism Compound Library
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High-Throughput Bioactive Compound Library
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Biological Activity
IC50: 0.021 μM (GLS1)
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
12.59 nM
Compound: 6a
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Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-glo assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-glo assay
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[PMID: 37849538] |
| CHO | IC50 |
>33.3 μM
Compound: 27
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Inhibition of human ERG expressed in CHO cells by Ionworks electrophysiology assay
Inhibition of human ERG expressed in CHO cells by Ionworks electrophysiology assay
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[PMID: 31199640] |
| NCI-H1703 | GI50 |
0.011 μM
Compound: 27
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Antiproliferative activity against human NCI-H1703 cells assessed as reduction in cell growth after 5 days by SYTOX green staining-based assay
Antiproliferative activity against human NCI-H1703 cells assessed as reduction in cell growth after 5 days by SYTOX green staining-based assay
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[PMID: 31199640] |
Chemical Information
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CAS No. 1832646-52-2
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Appearance Solid
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Molecular Weight 411.48
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Formula C19H21N7O2S
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Color White to light yellow
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SMILES
O=C([C@H](C1=CC=CC=C1)OC)NC2=NN=C(S2)N[C@H]3CN(C4=CC=CN=N4)CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 20 mg/mL (48.61 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4303 mL | 12.1513 mL | 24.3025 mL | 60.7563 mL |
| 5 mM | 0.4861 mL | 2.4303 mL | 4.8605 mL | 12.1513 mL | |
| 10 mM | 0.2430 mL | 1.2151 mL | 2.4303 mL | 6.0756 mL | |
| 15 mM | 0.1620 mL | 0.8101 mL | 1.6202 mL | 4.0504 mL | |
| 20 mM | 0.1215 mL | 0.6076 mL | 1.2151 mL | 3.0378 mL | |
| 25 mM | 0.0972 mL | 0.4861 mL | 0.9721 mL | 2.4303 mL | |
| 30 mM | 0.0810 mL | 0.4050 mL | 0.8101 mL | 2.0252 mL | |
| 40 mM | 0.0608 mL | 0.3038 mL | 0.6076 mL | 1.5189 mL |
GLS1 Inhibitor-1 Related Classifications
HY-136704 Related Classifications
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