3,6-Bis(1-methylpropyl)-2(1H)-pyrazinone
3,6-Bis(1-methylpropyl)-2(1H)-pyrazinone is an alkylated 2(1H)-pyrazinone derivative and cytotoxic agent found in the tunicate-derived actinomycete Streptomyces sp. Did-27.3,6-Bis(1-methylpropyl)-2(1H)-pyrazinone exhibits cytotoxic activity against cancer cells.3,6-Bis(1-methylpropyl)-2(1H)-pyrazinone can be used for the research of colorectal carcinoma, hepatocellular carcinoma, breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 17005-09-3
- Formula: C12H20N2O
- Molecular Weight:208.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
In Vitro
3,6-Bis(1-methylpropyl)-2(1H)-pyrazinone (compound 6) shows moderate antiproliferative activity against HCT-116 and MCF-7 cells, with IC50 values of 18 μM and 10 μM respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116, HepG2 and MCF-7 cells
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Concentration:IC50 assay
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Incubation Time:/
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Result:Showed moderate antiproliferative activity against HCT-116 and MCF-7 cells, with IC50 of 18 μM and 10 μM respectively, and weak activity against HepG2 cells with an IC50 ≥ 50 μM.
Chemical Information
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CAS No. 17005-09-3
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Molecular Weight 208.30
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Formula C12H20N2O
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SMILES
O=C1NC(C(CC)C)=CN=C1C(CC)C
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Structure Classification
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Initial Source
Streptomyces sp
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)