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Setmelanotide TFA

(Synonyms: RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA)
8 Cited Publications
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Based on 8 publication(s) in Google Scholar

Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.

For research use only. We do not sell to patients.

  • Formula: C51H69F3N18O11S2
  • Molecular Weight:1231.33
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Setmelanotide TFA Chemical Structure
    Setmelanotide TFA Chemical Structure
  • Experimental Validation Results for Setmelanotide TFA
  • Experimental Validation Results for Setmelanotide TFA
  • Experimental Validation Results for Setmelanotide TFA
  • Experimental Validation Results for Setmelanotide TFA
  • Experimental Validation Results for Setmelanotide TFA
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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In Vivo Efficacy StudyBio/Physico-chemical Assay
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  • Bio/Physico-chemical Assay
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All Melanocortin Receptor Isoforms

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100 mg

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  • Setmelanotide TFA Chemical Structure
    Setmelanotide TFA Chemical Structure
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    Setmelanotide TFA purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2025 Jan 15;17(781):eadr6459. [Abstract]

    Customer Validation
     Setmelanotide (2 mg/kg; i.p.; once daily for 9 d) reduced body weights and food intake and improved glucose tolerance of HFD-fed OtpQ153R/+ mice, which quickly regained body weight after the treatment was discontinued.

  • 1/16

    Setmelanotide TFA purchased from MedChemExpress. Usage Cited in: J Exp Med. 2021 Jul 5;218(7):e20202484. [Abstract]

    Customer Validation
     Setmelanotide (100 nM) blocked the risperidone-induced hyperpolarization of MC4RPVH neurons.

  • 1/16

    Setmelanotide TFA purchased from MedChemExpress. Usage Cited in: J Exp Med. 2021 Jul 5;218(7):e20202484. [Abstract]

    Customer Validation
     A single dose of Setmelanotide (SET) (2 mg/kg; i.p.) suppressed fast-induced refeeding in Mc4rfl/fl mice.

  • 1/16

    Setmelanotide TFA purchased from MedChemExpress. Usage Cited in: J Exp Med. 2021 Jul 5;218(7):e20202484. [Abstract]

    Customer Validation
     Infusion of Setmelanotide (SET) (2 mg/kg; once daily for 14 d) attenuated hyperphagia in C57BL/6 mice fed with risperidone.

  • 1/16

    Setmelanotide TFA purchased from MedChemExpress. Usage Cited in: J Exp Med. 2021 Jul 5;218(7):e20202484. [Abstract]

    Customer Validation
     Setmelanotide (SET) (2 mg/kg; once daily for 14 d) caused accelerated glucose clearance of C57BL/6 mice fed with risperidone in a GTT.

  • Setmelanotide TFA