TDI-11904

Cat. No.: HY-182448: Data Sheet Handling Instructions
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TDI-11904 is a peripherally active EZH2 inhibitor with an EZH2 IC₅₀ of 0.9 nM. TDI-11904 inhibits EZH2 methyltransferase activity, reduces the trimethylation level of H3K27me3, and decreases intracellular H3K27me3 content. TDI-11904 inhibits the proliferation of lymphoma cells. TDI-11904 can be used for the research of lymphoma.

For research use only. We do not sell to patients.

TDI-11904 Chemical Structure

CAS No. : 3056015-44-9

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•Related Small Molecules:

•Related Proteins:

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-422	IC₅₀	125 nM Compound: 21	Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 72 hrs followed by compound dilution in growth medium and measured after 96 hrs by Alamar blue assay Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition incubated for 72 hrs followed by compound dilution in growth medium and measured after 96 hrs by Alamar blue assay	[PMID: 35300079]

In Vitro

TDI-11904 inhibits H3K27me3 in Karpas-422 cells with an IC₅₀ of 6.0 nM^[1].
TDI-11904 inhibits Karpas-422 cell proliferation with an IC₅₀ of 125 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

507.43

Formula

C₂₃H₂₄Cl₂N₄O₃S

CAS No.

3056015-44-9

SMILES

O=C1NC(C)=CC(SC)=C1CN2C(C3=C(C(C4=C(C)ON=C4C)=CC(Cl)=C3N(CC2)C)Cl)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liang R, et al. A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors. ACS Med Chem Lett. 2022;13(3):377-387. Published 2022 Feb 10. [Content Brief]

TDI-11904 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TDI-119043056015-44-9TDI11904TDI 11904Histone Methyltransferaselymphoma cellshistone-3 lysine 27 trimethylationH3K27me3EZH2methyltransferase activityMDR1 efflux transporterlymphomaKarpas-422 cellsInhibitorinhibitorinhibit

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