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Cat. No.: HY-168030

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hCAIX-IN-23

hCAIX-IN-23 (Compound 27) is a human carbonic anhydrase (hCA) inhibitor with K_i values of 10.4 and 8.5 nM for hCA IX and hCA XII, respectively. In addition to inhibiting hCA activity, hCAIX-IN-23 releases NO, exhibiting dual antitumor activity. hCAIX-IN-23 induces apoptosis by regulating mitochondrial caspase activity and the ferroptosis pathway (ferroptosis) through the downregulation of hCA IX and iron-regulatory protein expression. hCAIX-IN-23 is useful for renal cancer research.

For research use only. We do not sell to patients.

Formula: C₂₂H₂₀N₄O₅S
Molecular Weight:452.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

hCAIX-IN-23 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

hCA IX

10.4 nM (Ki)

hCA XII

8.5 nM (Ki)

All Carbonic Anhydrase Isoforms :

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A498	IC₅₀	2 μM Compound: 27; C-27	Antiproliferative activity against human A498 cells expressing human CA IX assessed as inhibition of cell growth by celltiter-glo assay Antiproliferative activity against human A498 cells expressing human CA IX assessed as inhibition of cell growth by celltiter-glo assay	[PMID: 39207927]
A498	IC₅₀	3 μM Compound: 27; C-27	Antiproliferative activity against human A498 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo cell viability assay Antiproliferative activity against human A498 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo cell viability assay	[PMID: 39207927]
A498	IC₅₀	3 μM Compound: 27; C-27	Antiproliferative activity against human A498 cells assessed as inhibition of cell growth incubated for 96 hrs by cell-titer glo cell viability assay Antiproliferative activity against human A498 cells assessed as inhibition of cell growth incubated for 96 hrs by cell-titer glo cell viability assay	[PMID: 39207927]
AGS	IC₅₀	3.5 μM Compound: 27; C-27	Antiproliferative activity against human AGS cells assessed as inhibition of cell growth incubated for 96 hrs by cell-titer glo cell viability assay Antiproliferative activity against human AGS cells assessed as inhibition of cell growth incubated for 96 hrs by cell-titer glo cell viability assay	[PMID: 39207927]
AGS	IC₅₀	4 μM Compound: 27; C-27	Antiproliferative activity against human AGS cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo cell viability assay Antiproliferative activity against human AGS cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo cell viability assay	[PMID: 39207927]
CWR22R	IC₅₀	6.2 μM Compound: 27; C-27	Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 96 hrs by cell-titer glo cell viability assay Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 96 hrs by cell-titer glo cell viability assay	[PMID: 39207927]
CWR22R	IC₅₀	6.9 μM Compound: 27; C-27	Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo cell viability assay Antiproliferative activity against human 22Rv1 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo cell viability assay	[PMID: 39207927]
PC-3	IC₅₀	4.8 μM Compound: 27; C-27	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo cell viability assay Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by cell-titer glo cell viability assay	[PMID: 39207927]
PC-3	IC₅₀	4.8 μM Compound: 27; C-27	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 96 hrs by cell-titer glo cell viability assay Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 96 hrs by cell-titer glo cell viability assay	[PMID: 39207927]

Chemical Information

Molecular Weight 452.48
Formula C₂₂H₂₀N₄O₅S
SMILES

O=C(N(CCC1=CC=C(C=C1)S(=O)(N)=O)CC2=CC=CC=C2)C3=CC4=NO[N+]([O-])=C4C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bua S, et al. Harnessing Nitric Oxide-Donating Benzofuroxans for Targeted Inhibition of Carbonic Anhydrase IX in Cancer. J Med Chem. 2024 Sep 12;67(17):15892-15907. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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hCAIX-IN-23

All Carbonic Anhydrase Isoforms

All Caspase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

hCAIX-IN-23 Related Classifications

HY-168030 Related Classifications