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Cat. No.: HY-153515

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Renin IN-2

Renin IN-2 (compound 27) is an orally active human renin inhibitor with an IC₅₀ of 0.059 μM. Renin IN-2 can be used in the research of hypertension.

For research use only. We do not sell to patients.

CAS No.: 2109805-77-6
Formula: C₂₀H₂₄FN₃O
Molecular Weight:341.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Renin IN-2 Chemical Structure

CAS No.: 2109805-77-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Renin IN-2 (compound 27) is an orally active human renin inhibitor with an IC₅₀ of 0.059 μM. Renin IN-2 can be used in the research of hypertension^[1].

In Vitro

Renin IN-2 (compound 27) potently inhibits human renin with an IC₅₀ of 0.059 μM, has a ligand efficiency of 0.39^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	V_dss	CL	Bioavailability	AUC_0-24	C_max
Rat^[1]	1 mg/kg	i.v.	2.2 h	10 L/kg	68 mL/min/kg	/	/	/
Rat^[1]	10 mg/kg	p.o.	/	/	/	20 %	473 ng·h/mL	87 ng/mL

Chemical Information

CAS No. 2109805-77-6
Molecular Weight 341.43
Formula C₂₀H₂₄FN₃O
SMILES

FC=1C=CC(=C2NC(=C(C12)C)CCOC)C3=C(N=C(N)C=C3C)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cloudsdale IS, et al. Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations. Bioorg Med Chem. 2017;25(15):3947-3963. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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