2. Metabolic Enzyme/Protease
  3. Renin
  4. Renin IN-2

Renin IN-2 (compound 27) is a human renin inhibitor with an IC50 of 0.059 μM. Renin IN-2 exhibits oral efficacy. Renin IN-2 can be used in the research of hypertension.

For research use only. We do not sell to patients.

Renin IN-2

Renin IN-2 Chemical Structure

CAS No. : 2109805-77-6

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Renin IN-2 Related Antibodies

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Description

Renin IN-2 (compound 27) is a human renin inhibitor with an IC50 of 0.059 μM. Renin IN-2 exhibits oral efficacy. Renin IN-2 can be used in the research of hypertension[1].

In Vitro

Renin IN-2 (compound 27) potently inhibits human renin with an IC50 of 0.059 μM, has a ligand efficiency of 0.39[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Renin IN-2 Related Antibodies
Parmacokinetics
Species Dose Route T1/2 Vdss CL Bioavailability AUC0-24 Cmax
Rat[1] 1 mg/kg i.v. 2.2 h 10 L/kg 68 mL/min/kg / / /
Rat[1] 10 mg/kg p.o. / / / 20 % 473 ng·h/mL 87 ng/mL
In Vivo

Renin IN-2 (Comp 27) (1-10 mg/kg; i.v., p.o.; single dose) exhibits an oral bioavailability of 20% in healthy Sprague Dawley rats, with a maximum plasma concentration of 87 ng/mL after a single 10 mg/kg oral gavage dose[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

341.43

Formula

C20H24FN3O
CAS No.
SMILES

FC=1C=CC(=C2NC(=C(C12)C)CCOC)C3=C(N=C(N)C=C3C)CC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Renin IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Renin IN-22109805-77-6Renin IN2Renin IN 2Reninhuman reninratsSprague Dawley ratshypertensionInhibitorinhibitorinhibit

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