EBI3 Antibody
(Synonyms: EBI3, IL27B, Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, cytokine receptor, EBI3, EBV induced gene 3 protein,)EBI3 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to EBI3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), 0.05% NaN3, 40% Glycerol
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:50-100 |
Product Details
EBI3 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to EBI3.
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Host Rabbit
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Clonality polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 25 kDa;
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 25 kDa
Fusion protein of human EBI3
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), 0.05% NaN3, 40% Glycerol
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
EBI3 associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines
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Subcellular Localization
Secreted
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Expression
Induction: By Epstein-Barr virus (EBV). -
Isoforms & Post-Translational Modification
EBI3 has an amino acid length of 229, molecular weight is 25396 Da.EBI3 的氨基酸个数为 229 个，分子量为 25396 Da。
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Subunit
Heterodimer with IL27/IL27A; not disulfide-linked.
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SwissProt ID
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Synonyms
EBI3, IL27B, Interleukin-27 subunit beta, IL-27 subunit beta, IL-27B, Epstein-Barr virus-induced gene 3 protein, EBV-induced gene 3 protein, cytokine receptor, EBI3, EBV induced gene 3 protein,
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