DC07090
DC07090 is a potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 879070-72-1
- Fòrmula: C18H14N4O
- Peso molecular:302.33
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
IC50: 21.72 μM (EV71 3C protease)[1].
Ki: 23.29 μM (EV71 3C protease)[1].
EC50: 27.76 μM (coxsackievirus A16)[1]
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| RD | CC50 |
>200 μM
Compound: DC07090
|
Cytotoxicity against human RD cells after 48 hrs by CellTiter-glo luminescent cell viability assay
Cytotoxicity against human RD cells after 48 hrs by CellTiter-glo luminescent cell viability assay
|
[PMID: 27776325] |
In Vitro
DC07090 forms stable hydrogen-bonding interactions with the main chains of S128, G145, G164 and hydrophobic interactions with F25, L125, L127 and F170. DC07090 (0.01~10 μM) shows micromolar potency against EV71 3Cpro. DC07090 exhibits a highly inhibitory potency on EV71 replication with an EC50 value of 22.09 μM. DC07090 inhibits CVA16 with an EC50 value of 27.76 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
No. CAS 879070-72-1
-
Peso molecular 302.33
-
Fòrmula C18H14N4O
-
SMILES
C1(C(C=C2)=CC=C2NCC3=NC=CC=C3)=NC(N=CC=C4)=C4O1
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DC07090 Related Classifications
HY-123517A Related Classifications
Powered by Bioz