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Cat. No.: HY-123517A

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DC07090

DC07090 is a potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC₅₀ and a K_i value for 21.72 μM and 23.29 μM. DC07090 could also inhibit coxsackievirus A16 (CVA16) replication with an EC₅₀ value of 27.76 μM.

For research use only. We do not sell to patients.

CAS No.: 879070-72-1
Formula: C₁₈H₁₄N₄O
Molecular Weight:302.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

DC07090 Chemical Structure

CAS No.: 879070-72-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 21.72 μM (EV71 3C protease)^[1].
Ki: 23.29 μM (EV71 3C protease)^[1].
EC50: 27.76 μM (coxsackievirus A16)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
RD	CC₅₀	>200 μM Compound: DC07090	Cytotoxicity against human RD cells after 48 hrs by CellTiter-glo luminescent cell viability assay Cytotoxicity against human RD cells after 48 hrs by CellTiter-glo luminescent cell viability assay	[PMID: 27776325]

In Vitro

DC07090 forms stable hydrogen-bonding interactions with the main chains of S128, G145, G164 and hydrophobic interactions with F25, L125, L127 and F170. DC07090 (0.01~10 μM) shows micromolar potency against EV71 3Cpro. DC07090 exhibits a highly inhibitory potency on EV71 replication with an EC₅₀ value of 22.09 μM. DC07090 inhibits CVA16 with an EC₅₀ value of 27.76 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 879070-72-1
Molecular Weight 302.33
Formula C₁₈H₁₄N₄O
SMILES

C1(C(C=C2)=CC=C2NCC3=NC=CC=C3)=NC(N=CC=C4)=C4O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ma GH, et al. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur J Med Chem. 2016 Nov 29;124:981-991. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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