PAD3-IN-1
PAD3-IN-1 (compound 14b) is an inhibitor of protein arginine deiminase (PAD) and is more than 10-fold more selective for PAD3 than PAD 1, 2, and 4. The IC50 values of PAD3-IN-1 for PAD 1, 2, 3, and 4 are 120, 27.5, 4.5, and 30.5 μM, respectively. And PAD3 is a PAD isoform associated with neurodegenerative responses to spinal cord injury, and PAD3-IN-1 could be used to study PAD-related neurological diseases.
For research use only. We do not sell to patients.
- CAS No.: 1671088-84-8
- Formula: C21H22Cl2N4O2
- Molecular Weight:433.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 120 μM (PAD1)[1]. IC50: 27.5 μM (PAD2)[1]. IC50: 4.5 μM (PAD3)[1]. IC50: 30.5 μM (PAD4)[1].
Chemical Information
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CAS No. 1671088-84-8
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Molecular Weight 433.33
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Formula C21H22Cl2N4O2
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SMILES
N=C(NCCCC(C(N1CC2=CC(C3=CC=CC=C3Cl)=CC=C2)=O)NC1=O)CCl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PAD3-IN-1 Related Classifications
HY-139088 Related Classifications
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