1671088-84-8
Chemical Structure
PAD3-IN-1
- CAS No.: 1671088-84-8
- Formula:C21H22Cl2N4O2
- Molecular Weight:433.33
IUPAC Name: 2-chloro-N-(3-(1-((2'-chloro-[1,1'-biphenyl]-3-yl)methyl)-2,5-dioxoimidazolidin-4-yl)propyl)acetimidamide
InChIKey: WBAMTPWAOJULCC-UHFFFAOYSA-N
SMILES: N=C(NCCCC(C(N1CC2=CC(C3=CC=CC=C3Cl)=CC=C2)=O)NC1=O)CCl
Biological Activity: PAD3-IN-1 (compound 14b) is an inhibitor of protein arginine deiminase (PAD) and is more than 10-fold more selective for PAD3 than PAD 1, 2, and 4. The IC50 values of PAD3-IN-1 for PAD 1, 2, 3, and 4 are 120, 27.5, 4.5, and 30.5 μM, respectively. And PAD3 is a PAD isoform associated with neurodegenerative responses to spinal cord injury, and PAD3-IN-1 could be used to study PAD-related neurological diseases[1].
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PAD3-IN-1 | PAD3-IN-1 (compound 14b) is an inhibitor of protein arginine deiminase (PAD) and is more than 10-fold more selective for PAD3 than PAD 1, 2, and 4. The IC50 values of PAD3-IN-1 for PAD 1, 2, 3, and 4 are 120, 27.5, 4.5, and 30.5 μM, respectively. And PAD3 is a PAD isoform associated with neurodegenerative responses to spinal cord injury, and PAD3-IN-1 could be used to study PAD-related neurological diseases. | |||||||||||||||||||||
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Keywords
