KW-2478 hydrochloride
Based on 4 publication(s) in Google Scholar
KW-2478 hydrochloride is an HSP90 inhibitor (IC50 = 3.8 nM). KW-2478 hydrochloride inhibits the growth and induces apoptosis in chronic myeloid leukemia (CML) cells and liver cancer cells. KW-2478 hydrochloride weakens the BCR/ABL and MAPK signaling pathways, leading to increased p27 and p21 expression and decreased cyclin B1 expression. KW-2478 hydrochloride downregulates STAT3 expression. KW-2478 hydrochloride may be used in research on cancers such as CML and liver cancer.
For research use only. We do not sell to patients.
- CAS No.: 819812-18-5
- Formula: C30H43ClN2O9
- Molecular Weight:611.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) KW-2478 hydrochloride
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Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 819812-18-5
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Molecular Weight 611.12
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Formula C30H43ClN2O9
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SMILES
O=C(N(CCOC)CCOC)CC1=C(C(C2=CC=C(OCCN3CCOCC3)C(OC)=C2)=O)C(O)=CC(O)=C1CC.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Exp Mol Med
2025 Jun;57(6):1308-1323. PMID: 40583061 -
Int J Mol Sci
2023 Nov 4;24(21):15971. PMID: 37958953 -
J Biol Chem
2024 Jan;300(1):105536. PMID: 38092149 -
Vet Microbiol
HSP90 inhibitors 17-AAG and VER-82576 inhibit porcine deltacoronavirus replication in vitro. [Abstract]2022 Feb:265:109316. PMID: 34954542
Purity & Documentation
References
[1]. eng D, et al. The HSP90 inhibitor KW-2478 depletes the malignancy of BCR/ABL and overcomes the imatinib-resistance caused by BCR/ABL amplification. Exp Hematol Oncol. 2022 May 27;11(1):33. [Content Brief]
[2]. Chang X, et al. Effect of Hsp90 Inhibitor KW-2478 on HepG2 Cells. Anticancer Agents Med Chem. 2019;19(18):2231-2242. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KW-2478 hydrochloride Related Classifications
HY-13468A Related Classifications
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