hURAT1 inhibitor 1
hURAT1 inhibitor 1 (compound 27b) is an isomarine-based, orally active dual hURAT1/GLUT9 inhibitor with IC50s of 0.16 μM and 4.47 μM, respectively, and has anti-hyperuricemia effects. hURAT1 inhibitor 1 showed significant uric acid-lowering activity in a hyperuricemia mouse model (10 mg/kg dose). hURAT1 inhibitor 1 had no significant in vitro cytotoxicity or in vivo hepatotoxicity and showed good PK characteristics.
For research use only. We do not sell to patients.
- Formula: C24H19BrO4
- Molecular Weight:451.31
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 0.16 μM (hURAT1); 4.47 μM (GLUT9)[1]
Chemical Information
-
Molecular Weight 451.31
-
Formula C24H19BrO4
-
SMILES
C/C(C(O)=O)=C/CC1=C2C(C(CC(C3=C(C=CC=C4)C4=C(Br)C=C3)O2)=O)=CC=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hURAT1 inhibitor 1 Related Classifications
HY-162829 Related Classifications
Powered by Bioz