2,3,4-Trihydroxybenzoic acid
Based on 1 Customer Validation
2,3,4-Trihydroxybenzoic acid is an α-amylase inhibitor with an IC50 of 17.30 mM against porcine α-amylase. 2,3,4-Trihydroxybenzoic acid increases cellular p21 and p27 protein levels. 2,3,4-Trihydroxybenzoic acid inhibits cancer cell growth and delays starch digestion to suppress postprandial hyperglycemia. 2,3,4-Trihydroxybenzoic acid can be used in research related to colorectal cancer, breast cancer and type 2 diabetes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.79%
- CAS 番号: 610-02-6
- 分子式: C7H6O5
- 分子量:170.12
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保管条件:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-W016993R
2,3,4-Trihydroxybenzoic acid (Standard)Standard of 2,3,4-Trihydroxybenzoic acid -
HY-Y0202
Pyrocatechuic acid -
HY-W012575
2,4-Dihydroxybenzoic acidCoQ precursor molecule Analogue -
HY-W010253
BenzylureaMTCH2 Inhibitor -
HY-Y0801
2,6-Dihydroxybenzoic acidAromatic Compound -
HY-Y0202R
Pyrocatechuic acid (Standard) -
HY-W008097
3,3-Dimethylglutaric acidOrganic Acid Derivative -
HY-W006230
Anthraflavic acidcytochrome P-448 Inhibitor -
HY-Y0801R
2,6-Dihydroxybenzoic acid (Standard)Aromatic Compound -
HY-W010253R
Benzylurea (Standard)Standard -
HY-W012575R
2,4-Dihydroxybenzoic acid (Standard)CoQ precursor molecule Analogue -
HY-W008097R
3,3-Dimethylglutaric acid (Standard)Reference Standard
生物活性
製品説明
体外実験
2,3,4-Trihydroxybenzoic acid (24-72 h) inhibits the proliferation of HCT-116 colon cancer cells in vitro[1].
2,3,4-Trihydroxybenzoic acid inhibits colony formation of HCT-116 colon cancer cells in vitro[1].
2,3,4-Trihydroxybenzoic acid inhibits colony formation of MDA-MB-231 breast cancer cells in vitro, and MDA-MB-231 cells are more sensitive than HCT-116 colon cancer cells[1].
2,3,4-Trihydroxybenzoic acid increases the protein levels of p21 and p27 in HCT-116 colon cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 610-02-6
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性状 Solid
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分子量 170.12
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分子式 C7H6O5
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Color White to off-white
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SMILES
O=C(O)C1=CC=C(O)C(O)=C1O
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別名
Benzoic acid, 2,3,4-trihydroxy-; ピロガロール-4-カルボン酸; 2,3,4-トリヒドロキシ安息香酸
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (293.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.70 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.70 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (274 KB)
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SDS (394 KB)
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- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 5.8782 mL | 29.3910 mL | 58.7820 mL | 146.9551 mL |
| 5 mM | 1.1756 mL | 5.8782 mL | 11.7564 mL | 29.3910 mL | |
| 10 mM | 0.5878 mL | 2.9391 mL | 5.8782 mL | 14.6955 mL | |
| 15 mM | 0.3919 mL | 1.9594 mL | 3.9188 mL | 9.7970 mL | |
| 20 mM | 0.2939 mL | 1.4696 mL | 2.9391 mL | 7.3478 mL | |
| 25 mM | 0.2351 mL | 1.1756 mL | 2.3513 mL | 5.8782 mL | |
| 30 mM | 0.1959 mL | 0.9797 mL | 1.9594 mL | 4.8985 mL | |
| 40 mM | 0.1470 mL | 0.7348 mL | 1.4696 mL | 3.6739 mL | |
| 50 mM | 0.1176 mL | 0.5878 mL | 1.1756 mL | 2.9391 mL | |
| 60 mM | 0.0980 mL | 0.4899 mL | 0.9797 mL | 2.4493 mL | |
| 80 mM | 0.0735 mL | 0.3674 mL | 0.7348 mL | 1.8369 mL | |
| 100 mM | 0.0588 mL | 0.2939 mL | 0.5878 mL | 1.4696 mL |
2,3,4-Trihydroxybenzoic acid 関連分類
HY-W016993 関連分類
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