2,3,4-Trihydroxybenzoic acid
Based on 1 Customer Validation
2,3,4-Trihydroxybenzoic acid is an α-amylase inhibitor with an IC50 of 17.30 mM against porcine α-amylase. 2,3,4-Trihydroxybenzoic acid increases cellular p21 and p27 protein levels. 2,3,4-Trihydroxybenzoic acid inhibits cancer cell growth and delays starch digestion to suppress postprandial hyperglycemia. 2,3,4-Trihydroxybenzoic acid can be used in research related to colorectal cancer, breast cancer and type 2 diabetes.
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- Purity: 99.79%
- CAS No.: 610-02-6
- 화학식: C7H6O5
- 분자량:170.12
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보관:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
2,3,4-Trihydroxybenzoic acid (24-72 h) inhibits the proliferation of HCT-116 colon cancer cells in vitro[1].
2,3,4-Trihydroxybenzoic acid inhibits colony formation of HCT-116 colon cancer cells in vitro[1].
2,3,4-Trihydroxybenzoic acid inhibits colony formation of MDA-MB-231 breast cancer cells in vitro, and MDA-MB-231 cells are more sensitive than HCT-116 colon cancer cells[1].
2,3,4-Trihydroxybenzoic acid increases the protein levels of p21 and p27 in HCT-116 colon cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 610-02-6
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Appearance Solid
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분자량 170.12
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화학식 C7H6O5
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Color White to off-white
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SMILES
O=C(O)C1=CC=C(O)C(O)=C1O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
용액&용해도
DMSO : 50 mg/mL (293.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.70 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.70 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (293 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.8782 mL | 29.3910 mL | 58.7820 mL | 146.9551 mL |
| 5 mM | 1.1756 mL | 5.8782 mL | 11.7564 mL | 29.3910 mL | |
| 10 mM | 0.5878 mL | 2.9391 mL | 5.8782 mL | 14.6955 mL | |
| 15 mM | 0.3919 mL | 1.9594 mL | 3.9188 mL | 9.7970 mL | |
| 20 mM | 0.2939 mL | 1.4696 mL | 2.9391 mL | 7.3478 mL | |
| 25 mM | 0.2351 mL | 1.1756 mL | 2.3513 mL | 5.8782 mL | |
| 30 mM | 0.1959 mL | 0.9797 mL | 1.9594 mL | 4.8985 mL | |
| 40 mM | 0.1470 mL | 0.7348 mL | 1.4696 mL | 3.6739 mL | |
| 50 mM | 0.1176 mL | 0.5878 mL | 1.1756 mL | 2.9391 mL | |
| 60 mM | 0.0980 mL | 0.4899 mL | 0.9797 mL | 2.4493 mL | |
| 80 mM | 0.0735 mL | 0.3674 mL | 0.7348 mL | 1.8369 mL | |
| 100 mM | 0.0588 mL | 0.2939 mL | 0.5878 mL | 1.4696 mL |
2,3,4-Trihydroxybenzoic acid Related Classifications
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