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Cat. No.: HY-182712

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HPSE-IN-2

HPSE-IN-2 is a heparanase (HPSE) inhibitor with an IC₅₀ of 0.27 µM. HPSE-IN-2 reduces lung metastasis in mouse models. HPSE-IN-2 can be used for the research of melanoma.

For research use only. We do not sell to patients.

CAS No.: 53859-71-5
Formula: C₂₇H₂₀N₆O
Molecular Weight:444.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HPSE-IN-2 Chemical Structure

CAS No.: 53859-71-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

HPSE-IN-2 is a heparanase (HPSE) inhibitor with an IC₅₀ of 0.27 µM. HPSE-IN-2 reduces lung metastasis in mouse models. HPSE-IN-2 can be used for the research of melanoma^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
B16	Inhibition	50 % Compound: 7a	Inhibition of proliferation on B16-BL6 melanoma cells at 100 uM Inhibition of proliferation on B16-BL6 melanoma cells at 100 uM	[PMID: 16246560]

In Vivo

HPSE-IN-2 (Compound 12a) (30 mg/kg; i.p.; single dose) inhibits B16 melanoma lung metastasis in C57 mice by approximately 50%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57 (experimental metastasis model via tail vein injection of B16 melanoma cells)^[1]
Dosage:

30 mg/kg
Administration:

i.p.; single dose
Result:

Inhibited lung metastasis by approximately 50% compared to the vehicle-treated group.

Chemical Information

CAS No. 53859-71-5
Molecular Weight 444.49
Formula C₂₇H₂₀N₆O
SMILES

O=C(NC1=CC=C(C2=NC3=C(N2)C=CC=C3)C=C1)NC4=CC=C(C5=NC6=C(N5)C=CC=C6)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Miao HQ, et al. Development of heparanase inhibitors for anti-cancer therapy. Curr Med Chem. 2006;13(18):2101-2111. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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