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Cat. No.: HY-115390

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14,15-Dehydro Leukotriene B4

14,15-Dehydro Leukotriene B4 (Compound 4) is a LTB4 receptor antagonist. 14,15-Dehydro Leukotriene B4 also has a higher binding affinity for BLT1 with a K_i value of 27 nM and BLT2 with a K_i value of 473 nM. 14,15-Dehydro Leukotriene B4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC₅₀ value of 1 µM.

For research use only. We do not sell to patients.

CAS No.: 114616-11-4
Formula: C₂₀H₃₀O₄
Molecular Weight:334.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

14,15-Dehydro Leukotriene B4 Chemical Structure

CAS No.: 114616-11-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

BLT1

27 nM (Ki)

BLT2

473 nM (Ki)

All Leukotriene Receptor Isoforms :

Chemical Information

CAS No. 114616-11-4
Molecular Weight 334.45
Formula C₂₀H₃₀O₄
SMILES

CCCCCC#CC[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shimazaki T, et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins. 1990 Apr;39(4):459-67. [Content Brief]

[2]. Wang S, et al. A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. J Biol Chem. 2000 Dec 29;275(52):40686-94. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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14,15-Dehydro Leukotriene B4

Leukotriene B4

Leukotriene E4

Leukotriene B4 dimethyl amide

12-epi-LTB4

11-trans-Leukotriene C4

Atreleuton

Zafirlukast

Montelukast

Montelukast sodium

MK-571 sodium

15(S)-HPETE

Leukotriene C4

All Leukotriene Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

14,15-Dehydro Leukotriene B4

Leukotriene B4

Leukotriene E4

Leukotriene B4 dimethyl amide

12-epi-LTB4

11-trans-Leukotriene C4

Atreleuton

Zafirlukast

Montelukast

Montelukast sodium

MK-571 sodium

15(S)-HPETE

Leukotriene C4

All Leukotriene Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

14,15-Dehydro Leukotriene B4 Related Classifications

HY-115390 Related Classifications

Bioz