114616-11-4
Chemical Structure
14,15-Dehydro Leukotriene B4
- CAS No.: 114616-11-4
- Formula:C20H30O4
- Molecular Weight:334.45
IUPAC Name: (5S,6Z,8E,10E,12R)-5,12-dihydroxyicosa-6,8,10-trien-14-ynoic acid
InChIKey: PRCVOEPTHWOJMX-CHHAPGPYSA-N
SMILES: CCCCCC#CC[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O
Biological Activity: 14,15-Dehydro Leukotriene B4 (Compound 4) is a LTB4 receptor antagonist. 14,15-Dehydro Leukotriene B4 also has a higher binding affinity for BLT1 with a Ki value of 27 nM and BLT2 with a Ki value of 473 nM. 14,15-Dehydro Leukotriene B4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM[1][2].
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14,15-Dehydro Leukotriene B4 | 14,15-Dehydro Leukotriene B4 (Compound 4) is a LTB4 receptor antagonist. 14,15-Dehydro Leukotriene B4 also has a higher binding affinity for BLT1 with a Ki value of 27 nM and BLT2 with a Ki value of 473 nM. 14,15-Dehydro Leukotriene B4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM. | |||||||||||||||||||||
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- [1]. Shimazaki T, et al. Some newly synthesized leukotriene B4 analogs inhibit LTB4-induced lysozyme release from rat polymorphonuclear leukocytes. Prostaglandins. 1990 Apr;39(4):459-67. [Content Brief]
- [2]. Wang S, et al. A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. J Biol Chem. 2000 Dec 29;275(52):40686-94. [Content Brief]
Keywords
