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Cat. No.: HY-170508

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Aromatase-IN-4

Aromatase-IN-4 (Compound 6a) is an aromatase (Aromatase) inhibitor. Aromatase-IN-4 exhibits anticancer activity, with GI₅₀ values of 2.95 μM, 3.35 μM, 2.27 μM, 8.46 nM, and 1.56 μM against the MDAMB-231, MCF-7, A-549, NCI-H23, and A-498 cell lines, respectively. Aromatase-IN-4 effectively blocks aromatase-dependent estrogen production.

For research use only. We do not sell to patients.

CAS No.: 3060588-16-8
Formula: C₂₃H₁₈N₆
Molecular Weight:378.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Aromatase-IN-4 Chemical Structure

CAS No.: 3060588-16-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Aromatase-IN-4 (Compound 6a) is an aromatase (Aromatase) inhibitor. Aromatase-IN-4 exhibits anticancer activity, with GI₅₀ values of 2.95 μM, 3.35 μM, 2.27 μM, 8.46 nM, and 1.56 μM against the MDAMB-231, MCF-7, A-549, NCI-H23, and A-498 cell lines, respectively^[1]. Aromatase-IN-4 effectively blocks aromatase-dependent estrogen production^[1].

All Cytochrome P450 Isoforms :

Chemical Information

CAS No. 3060588-16-8
Molecular Weight 378.43
Formula C₂₃H₁₈N₆
SMILES

C1(NC2=NC=C(NC3=CC=C(C4=NC5=C(N4)C=CC=C5)C=C3)C=C2)=CC=CN=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sabale P, et al. Molecular Docking, Synthesis and Biological Evaluation of New Benzimidazole‐Pyridine Derivatives as Potential Aromatase Inhibitor for the Treatment of Cancer[J]. ChemistrySelect, 2024, 9(37): e202401797.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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References

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Aromatase-IN-4

All Cytochrome P450 Isoforms