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Results for "

neuroprotective

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (418) Cardiovascular Disease (246) Endocrinology (36) Infection (210) Inflammation/Immunology (511) Metabolic Disease (202) Neurological Disease (1349)
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1545

Inhibitors & Agonists

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Biochemical Assay Reagents

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489

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Antibodies

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GMP Molecules

Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-B0034

Donepezil Hydrochloride 20+ Cited Publications E2020	Cholinesterase (ChE)	Neurological Disease Cancer
Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-15068

NBQX 15+ Cited Publications FG9202	iGluR	Neurological Disease
NBQX (FG9202) is a highly selective and competitive AMPA receptor antagonist. NBQX has neuroprotective and anticonvulsant activity .

HY-100347

SRI-011381 55+ Cited Publications	TGF-beta/Smad	Neurological Disease
SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects .

HY-P1932

Cortistatin-14	Somatostatin Receptor	Neurological Disease Inflammation/Immunology Endocrinology
Cortistatin-14 is a neuropeptide that shares structural similarities with somatostatin, working by binding to somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) has anticonvulsant, neuroprotective effects, and significant anti-inflammatory properties .

HY-100927

Ro 20-1724 Ro 20-174	Phosphodiesterase (PDE)	Neurological Disease
Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a K_i of 1930 nM. Neuroprotective effect .

HY-N0405

Orientin 5+ Cited Publications	TNF Receptor Interleukin Related	Neurological Disease Cancer
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N0576

Solanesol 2 Publications Verification	Endogenous Metabolite Heme Oxygenase (HO) HSP p38 MAPK Akt Apoptosis Caspase PARP	Neurological Disease Metabolic Disease Inflammation/Immunology
Solanesol is an orally active aliphatic terpene alcohol. Solanesol is mainly found in tobacco and other Solanaceae plants. Solanesol induces HO-1 and Hsp70 expression, activates p38 and Akt signaling pathways, and inhibits Apoptosis (reduces caspase-3 and PARP cleavage). Solanesol has antioxidant, anti-inflammatory, and neuroprotective activities. Solanesol can be used in the research of Huntington's disease, alcoholic liver disease, chronic inflammatory pain, anxiety, Alzheimer's disease, and bipolar disorder .

HY-15068A

NBQX disodium 15+ Cited Publications FG9202 disodium	iGluR	Neurological Disease
NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity .

HY-N1318

Salvigenin 5+ Cited Publications Psathyrotin	Autophagy Apoptosis ROS Kinase	Neurological Disease Inflammation/Immunology Cancer
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H₂O₂-induced cell apoptosis .

HY-W008613

Pamoic acid 5 Publications Verification Embonic acid	GPR35 ERK	Neurological Disease Inflammation/Immunology
Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC₅₀ of 79 nM. Pamoic acid exhibits neuroprotective and anti-inflammatory properties .

HY-N2195

Nootkatone 4 Publications Verification (+)-Nootkatone	Environmental Pollutants Interleukin Related TNF Receptor	Neurological Disease
Nootkatone, a neuroprotective agent from Vitis vinifera, has antioxidant and anti-inflammatory effects . Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease .

HY-P0133

(Arg) 9 Nona-L-arginine; Peptide R9	Ser/Thr Protease	Neurological Disease
(Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC₅₀ of 0.78 μM in the glutamic acid model .

HY-116622

α5IA L-822179	GABA Receptor	Neurological Disease
α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential .

HY-P0133A

(Arg)9 TFA 1 Publications Verification Nona-L-arginine TFA; Peptide R9 TFA	Ser/Thr Protease	Neurological Disease
(Arg)9 (Nona-L-arginine) TFA is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 TFA has neuroprotective property, exhibits neuroprotective activity with an IC₅₀ of 0.78 μM in the glutamic acid model .

HY-101445B

(S)-Trolox	Drug Isomer	Neurological Disease
(S)-Trolox is an analogue of vitamin E, in which the phytyl chain is replaced with a carboxyl group. (S)-Trolox is frequently used as a model compound for studies of structural features, as well as a standard for evaluation of antioxidant activity. (S)-Trolox has potent and specific neuroprotective and antioxidant effects .

HY-N2180

(+)-Eudesmin (+)-Eudesmine	PKC PKA p38 MAPK NO Synthase	Neurological Disease
Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furanoid lignin. Pinoresinol dimethyl ether can be isolated from Magnolia biondii. Pinoresinol dimethyl ether activates MAPK, PKC, and PKA upstream pathways and inhibits NO levels. Pinoresinol dimethyl ether has neuroprotective activity .

HY-P0133B

(Arg)9 acetate 1 Publications Verification Nona-L-arginine acetate; Peptide R9 acetate	Ser/Thr Protease	Neurological Disease
(Arg)9 (Nona-L-arginine) acetate is a cell-penetrating peptide (CPP) made up of 9 arginine residues. (Arg)9 acetate has neuroprotective property, exhibits neuroprotective activity with an IC₅₀ of 0.78 μM in the glutamic acid model .

HY-120007

JC124	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects .

HY-W742957

Pregnanolone sulfate (pyridinium)	iGluR	Neurological Disease
Pregnanolone sulfate pyridinium is an endogenous neurosteroid that inhibits NMDA receptors and is neuroprotective .

HY-108563

SC 51089 1 Publications Verification	Prostaglandin Receptor	Neurological Disease
SC 51089 is a selective antagonist of prostaglandin E₂ EP1 receptor, with K_is of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 exhibits neuroprotective activity .

HY-133813A

Apovincaminic acid hydrochloride salt	Drug Metabolite	Neurological Disease
Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action .

HY-108563A

SC 51089 free base 1 Publications Verification	Prostaglandin Receptor	Neurological Disease
SC 51089 free base is a selective antagonist of prostaglandin E₂ EP1 receptor, with K_is of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 free base exhibits neuroprotective activity .

HY-121095

Bizine	Histone Demethylase	Neurological Disease Cancer
Bizine, a Phenelzine analogue, is a potent and selective LSD1 inhibitor, with a b>K_i of 59 nM. Bizine can modulate bulk histone methylation in cancer cells. Bizine shows neuroprotective effects .

HY-N6880A

(-)-Rabdosiin	HIV	Infection Neurological Disease
(-)-Rabdosiin is a novel phenolic marker, found from Symphytum officinale L. (-)-Rabdosiin shows antioxidant, neuroprotective or anti-HIV activities .

HY-15071

YM90K	iGluR	Neurological Disease
YM90K is a potent and selective AMPA receptor antagonist with a K_i of 84 nM. YM90K is less potent in inhibiting kainate (K_i of 2.2 μM) and NMDA (K_i of 37 μM) receptors. YM90K has neuroprotective actions .

HY-118785

MSP-3	TRP Channel	Neurological Disease
MSP-3 is a potent TRPV1 agonist, with an EC₅₀ of 0.87 μM. MSP-3 exhibits neuroprotective and antinociceptive effects .

HY-133177

MS-153	EAAT	Neurological Disease
MS-153 is a glutamate transporter activator that can be used as a neuroprotective agent .

HY-151430

Nrf2/HO-1 activator 1	Keap1-Nrf2 ERK Akt JNK Reactive Oxygen Species (ROS)	Neurological Disease
Nrf2/HO-1 activator 1 (Compound 24) is a potent Nrf2/HO-1 activator, neuroprotective agent. Nrf2/HO-1 activator 1 shows neuroprotective and antioxidant activities. Nrf2/HO-1 activator 1 can be used in Parkinson's disease (PD) research .

HY-113631

Amorfrutin B	PPAR	Neurological Disease Metabolic Disease
Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with K_i values of 19 nM and EC₅₀ values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities .

HY-59208

4-Quinolinol Kynurine	Endogenous Metabolite	Neurological Disease Cancer
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

HY-178943

Neuroprotective agent 15	Cholinesterase (ChE) Cannabinoid Receptor Aldehyde Dehydrogenase (ALDH) Caspase Apoptosis	Neurological Disease
Neuroprotective agent 15 (Compound 3e) is a neuroprotective agent. Neuroprotective agent 15 is a selective butyrylcholinesterase (BChE) inhibitor, with IC₅₀ values of 2.6 and 114.3 μM for BChE and AChE respectively. Neuroprotective agent 15 has cannabinoid CB2 receptor (CB2 receptor) agonistic activity. Neuroprotective agent 15 can reduce cell death, LDH release and Caspase-3/7 activity, and inhibit apoptosis. Neuroprotective agent 15 can reduce the formation of superoxide free radicals, maintain cell morphology, and significantly lower oxidative stress levels. Neuroprotective agent 15 can be used in the research of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease .

HY-N9338

Guattegaumerine	Others	Neurological Disease
Guattegaumerine is a bisbenzylisoquinoline alkaloid?with antimitotic, cytotoxic and neuroprotective activities .

HY-163162

Anhydro-Ouabain	Interleukin Related TNF Receptor	Neurological Disease Inflammation/Immunology
Anhydro-Ouabain (compound 20) is a cardiotonic steroid which shows anti-inflammatory and neuroprotective activities and thus can be used in neurological research .

HY-117547

Licostinel ACEA-1021	iGluR	Neurological Disease
Licostinel (ACEA-1021) is a glycine receptor antagonist (IC₅₀: 59 nM). Licostinel has neuroprotective activity .

HY-127109B

Tisolagiline methylsulfate KDS2010 methylsulfate	Monoamine Oxidase	Neurological Disease
Tisolagiline (KDS2010) methylsulfate is the selective, reversible and orally active inhibitor for MAO-B with an IC₅₀ of 8 nM. Tisolagiline methylsulfate exhibits neuroprotective and anti-neuroinflammatory activities .

HY-W156961

LS-75	PARP	Neurological Disease
LS-75 is a PARP-1 inhibitor with blood-brain permeability and IC₅₀ value of 18 μM. LS-75 has neuroprotective activity .

HY-N5110

Marmesinin (-)-Marmesinin; Ammijin	Others	Neurological Disease
Marmesinin ((-)-Marmesinin), a natural coumarin, is a biosynthetic precursor of psoralen and linear furanocoumarins. Marmesinin exhibits significant neuroprotective activities against glutamate-induced toxicity .

HY-178048

Neuroprotective agent 13	Autophagy	Neurological Disease
Neuroprotective agent 13 is a brain-penetrant 1H-benzo[d]imidazoles compound with neuroprotective effect. Neuroprotective agent 13 can activate autophagy and clear SCMAS accumulation from iPSC-derived neural progenitor cells. Neuroprotective agent 13 can be used for the research of neurological disease, such as neuronal ceroid lipofuscinoses (NCLs) .

HY-174339

Neuroprotective agent 12	Phosphodiesterase (PDE) Heme Oxygenase (HO) NF-κB	Neurological Disease Inflammation/Immunology
Neuroprotective agent 12 is an orally active and BBB-penetrable neuroprotective agent. Neuroprotective agent 12 has potent neuroprotective effects with robust anti-oxidation and anti-inflammation. Neuroprotective agent 12 significantly inhibits glutamate- and acrolein-induced cell death, reduces PDE4B expression but increases the HO-1, p-CREB and BDNF levels. Neuroprotective agent 12 exhibits potent neuroprotection in traumatic brain injury (TBI) mice model, promising for TBI and other central nervous system diseases .

HY-N7990

Scheffoleoside A	Others	Neurological Disease
Scheffoleoside A is a neuroprotective agent can be derived from Centella asiatica. Scheffoleoside A exhibits moderate activity in inhibiting 6-OHDA-induced cytotoxicity .

HY-N1318R

Salvigenin (Standard) Psathyrotin (Standard)	Reference Standards Autophagy Apoptosis ROS Kinase	Neurological Disease Inflammation/Immunology Cancer
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H2O2-induced cell apoptosis .

HY-N11920

Kadsurenin B	Platelet-activating Factor Receptor (PAFR)	Infection Neurological Disease Inflammation/Immunology
Kadsurenin B is a PAF (platelet-activating factor) antagonist with neuroprotective activity. Kadsurenin B has a wide range of pharmacological research potential, such as antibacterial, anti-inflammatory, neuroprotective, antioxidant, antiplatelet aggregation, cytotoxic, antiparasitic, etc .

HY-P10077

GL189	Beta-secretase	Neurological Disease
GL189 is a β-secretase inhibitor. GL189 has neuroprotective effect, and can be used for research of neurodegenerative diseases .

HY-P11244

150D4	Ephrin Receptor	Neurological Disease
150D4 is an efficient, selective, and blood-brain barrier penetrable EphA4 agonist. 150D4 has excitatory activity and neuroprotective effects. 150D4 can be used for research on neurological conditions .

HY-105450

GPI-3000	iGluR	Neurological Disease
GPI-3000 is a NMDA receptor antagonist. GPI-3000 can ameliorate metabolic injury and shows neuroprotective effect. GPI-3000 can be used for the researches of metabolic and neurological disease .

HY-121711

5-OH-HxMF	Apoptosis	Neurological Disease Inflammation/Immunology Cancer
5-OH-HxMF is a hydroxylated polymethoxyflavone that has anti-inflammatory, anticancer, neurotrophic and neuroprotective activities .

HY-15068AR

NBQX disodium (Standard) FG9202 disodium (Standard)	iGluR Reference Standards	Neurological Disease
NBQX (disodium) (Standard) is the analytical standard of NBQX (disodium). This product is intended for research and analytical applications. NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity .

HY-162165

Neuroprotective agent 4	Lipoxygenase	Neurological Disease
Neuroprotective agent 4 (compound 24a) is a novel and effective small molecule antioxidant. Neuroprotective agent 4 has a neuroprotective effect. Neuroprotective agent 4 can be used in the study of ischemic stroke and related diseases .

HY-172604

Neuroprotective agent 10	TNF Receptor Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Neuroprotective agent 10 (Compound 11c) is a brain-penetrant neuroprotective agent. Neuroprotective agent 10 scavenges ABTS radicals (scavenging IC₅₀: 9.20 μM), DPPH radicals (scavenging IC₅₀: 7.09 μM) and superoxide anion radicals (inhibition percentage: 48.4%). Neuroprotective agent 10 also alleviates H₂O₂-induced oxidative damage and LPS-induced neuroinflammation with antiepileptic activity. Neuroprotective agent 10 is promising for research of epilepsy and neuroprotection .

HY-161042

Neuroprotective agent 2	Caspase	Neurological Disease
Neuroprotective agent 2 (Compd 28) is a potent neuroprotective agent which has a protective effect in both salsolinol and glutamate-induced neurodegeneration models. Neuroprotective agent 2 reduces oxidative stress and caspase-3/7 activity in the glutamate model .

Cat. No.	Nom du produit	Category	Target	Chemical Structure

HY-N0055

Chlorogenic acid 25+ Cited Publications 3-O-Caffeoylquinic acid; Heriguard; NSC-407296	Caprifoliaceae Classification of Application Fields Lonicera japonica Thunb. Anti-aging Plants Endogenous metabolite Infection Human Gut Microbiota Metabolites Microorganisms Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Inflammation/Immunology Disease Research Fields Source Classification Cancer	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Bacterial Influenza Virus Endogenous Metabolite
Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound .

HY-N0092

Inosine 15+ Cited Publications	Productos naturales Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Adenosine Receptor Endogenous Metabolite
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-N0680

Thiamine hydrochloride 1 Publications Verification Thiamine chloride hydrochloride; Vitamin B1 hydrochloride	Structural Classification Productos naturales Human Gut Microbiota Metabolites Endogenous metabolite	Endogenous Metabolite Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB
Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes.Thiamine hydrochloride activates NrF-2/HO-1 and inhibits TLR4, NF-κB. Thiamine hydrochloride has neuroprotective and anti-inflammatory effects. Thiamine hydrochloride can be used in the studys of diabetic complications, neurological diseases, cancers, and colitis .

HY-N0418

Quercitrin 5+ Cited Publications Quercetin 3-rhamnoside	Flavonols Classification of Application Fields Erythrina stricta Roxb. Plants Compositae Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	Ribosomal S6 Kinase (RSK) Apoptosis Autophagy Reactive Oxygen Species (ROS)
Quercitrin (Quercetin 3-rhamnoside) is a bioflavonoid compound with potential anti-inflammation, antioxidative and neuroprotective effect. Quercitrin induces apoptosis of colon cancer cells. Quercitrin can be used for the research of cardiovascular and neurological disease research .

HY-N0820

Catalpol 10+ Cited Publications Catalpinoside	Neurological Disease Classification of Application Fields Anti-aging Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Infection Iridoids Terpenoids Scrophulariaceae Inflammation/Immunology Disease Research Fields Source Classification Cancer	HBV
Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0405

Orientin 5+ Cited Publications	Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	TNF Receptor Interleukin Related
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N0037

Albiflorin 5+ Cited Publications	Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Classification of Application Fields Terpenoids Plants Paeoniaceae Inflammation/Immunology Disease Research Fields Source Classification	Reactive Oxygen Species (ROS)
Albiflorin, a major constituent contained in peony root, is a brain-penetrant monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects .

HY-15121

L-Theanine 5 Publications Verification L-Glutamic Acid γ-ethyl amide; Nγ-Ethyl-L-glutamine	Microorganisms Neurological Disease Classification of Application Fields Anti-aging Amino acids Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae	Apoptosis Endogenous Metabolite Reactive Oxygen Species (ROS)
L-Theanine (L-Glutamic Acid γ-ethyl amide) is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective, anticancer and anti-oxidative activities. L-Theanine can pass through the blood–brain barrier and is orally active .

HY-N0889

Ginkgetin 10+ Cited Publications	Flavonoids Ginkgoaceae Classification of Application Fields Phenols Polyphenols Plants Biflavones Ginkgo biloba Disease Research Fields Source Classification Cancer	COX Wnt Apoptosis Autophagy
Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC₅₀ of 5.92 μΜ .

HY-N0520

Calycosin-7-O-β-D-glucoside 5 Publications Verification Calycosin-7-glucoside	Monophenols Flavonoids Classification of Application Fields Leguminosae Other Diseases Phenols Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Isoflavones Source Classification	Reactive Oxygen Species (ROS)
Calycosin-7-O-β-D-glucoside is an isoflavone isolated from Astragali Radix. Calycosin-7-O-β-D-glucoside has variety of biological activities, such as neuroprotective, cardioprotection, anti-inflammation, and antioxidative stress effects .

HY-N0931

Santacruzamate A 15+ Cited Publications CAY-10683	Alkaloids Microorganisms other families Classification of Application Fields Other Alkaloids Plants Disease Research Fields Source Classification Cancer	HDAC Amyloid-β
Santacruzamate A (CAY-10683, STA) is a potent and selective HDAC2 inhibitor with an IC₅₀ of 119 pM. STA also exerts neuroprotective property against amyloid-β protein fragment 25–35. STA can be used for cancer and neurological disease research .

HY-N0057

3,4-Dicaffeoylquinic acid 5+ Cited Publications 3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B	Infection Caprifoliaceae Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Source Classification	Glycosidase Influenza Virus Apoptosis Endogenous Metabolite
3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata, has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL .

HY-N0270

Ononin 10+ Cited Publications Ononoside; Formononetin 7-O-β-D-glucopyranoside	Structural Classification Flavonoids other families Classification of Application Fields Leguminosae Other Diseases Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Source Classification	ERK JNK p38 MAPK PI3K Akt mTOR Apoptosis
Ononin is an orally active isoflavone. Ononin inhibits the ERK/JNK/p38 and PI3K/Akt/mTOR pathways. Ononin regulates Apoptosis. Ononin has anti-tumor effects on laryngeal cancer and lung cancer. Ononin has neuroprotective effects. Ononin alleviates endoplasmic reticulum stress and diabetic nephropathy .

HY-N0576

Solanesol 2 Publications Verification	Other Terpenoids Structural Classification other families Neurological Disease Classification of Application Fields Terpenoids Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite Heme Oxygenase (HO) HSP p38 MAPK Akt Apoptosis Caspase PARP
Solanesol is an orally active aliphatic terpene alcohol. Solanesol is mainly found in tobacco and other Solanaceae plants. Solanesol induces HO-1 and Hsp70 expression, activates p38 and Akt signaling pathways, and inhibits Apoptosis (reduces caspase-3 and PARP cleavage). Solanesol has antioxidant, anti-inflammatory, and neuroprotective activities. Solanesol can be used in the research of Huntington's disease, alcoholic liver disease, chronic inflammatory pain, anxiety, Alzheimer's disease, and bipolar disorder .

HY-147059

Dieckol	Classification of Application Fields Anti-aging Marine natural products Metabolic Disease Infection Microorganisms Sunscreen Marine algae Phenols Polyphenols Cosmetic Research Disease Research Fields Source Classification Cancer	Bacterial
Dieckol, is a naturally occurring phlorotannin found in some brown algal species. Dieckol has anti-bacterial, anti-cancer, anti-oxidant, anti-aging, anti-diabetic, neuroprotective actions .

HY-N0272

Eleutheroside E 2 Publications Verification	Classification of Application Fields Lignans Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Apoptosis NF-κB
Eleutheroside E is an important component of ginseng that can be taken orally. Eleutheroside E has anti-inflammatory and antioxidant properties, and it helps reduce apoptosis in heart cells caused by hypoxia-reoxygenation (H/R) damage. Eleutheroside E can improve type 2 diabetes, enhance cognitive function, and has neuroprotective effects .

HY-N6778

Paxilline 5+ Cited Publications	Alkaloids Structural Classification Microorganisms other families Neurological Disease Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Indole Alkaloids Source Classification	Potassium Channel Calcium Channel Reactive Oxygen Species (ROS)
Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca ²⁺-stimulated ATPase (SERCA), with IC₅₀ values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity .

HY-N1318

Salvigenin 5+ Cited Publications Psathyrotin	Monophenols Flavonoids other families Neurological Disease Classification of Application Fields Flavones Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Autophagy Apoptosis ROS Kinase
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H₂O₂-induced cell apoptosis .

HY-N7560

Safranal 5+ Cited Publications	Ketones, Aldehydes, Acids Lridaceae Plants Crocus sativus L. Source Classification	Keap1-Nrf2
Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research .

HY-N2195

Nootkatone 4 Publications Verification (+)-Nootkatone	Structural Classification Terpenoids Sesquiterpenes Vitis vinifera cv. Zalema Plants Vitaceae Source Classification	Environmental Pollutants Interleukin Related TNF Receptor
Nootkatone, a neuroprotective agent from Vitis vinifera, has antioxidant and anti-inflammatory effects . Nootkatone improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease .

HY-N0748

Oxypaeoniflorin 4 Publications Verification	Other Monoterpenes Monophenols Paeonia lactiflora Pall. Terpenoids Phenols Plants Paeoniaceae Source Classification	Others
Oxypaeoniflorin, an anti-oxidant, is a monoterpene glycoside compound isolated from Paeoniae species. Oxypaeoniflorin has neuroprotective and anti-inflammatory effects .

HY-N3244

Moracin O 2 Publications Verification	Neurological Disease Classification of Application Fields Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn. Source Classification	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS)
Moracin O is a 2-arylbenzofuran isolated from the Morus alba Linn. . Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects .

HY-N6967

Levomenol (-)-α-Bisabolol	Structural Classification other families Terpenoids Sesquiterpenes Plants Source Classification	Environmental Pollutants Apoptosis
Levomenol ((-)-α-Bisabolol), a monocyclic sesquiterpene alcohol, exerts antioxidant, anti-inflammatory, and anti-apoptotic activities. Levomenol also has neuroprotective effects and prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. Levomenol attenuates nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Orally active .

HY-N0064

Macelignan 5+ Cited Publications (+)-Anwulignan; Anwuligan	Neurological Disease Classification of Application Fields Lignans Metabolic Disease Plants Monophenols Phenols Phenylpropanoids Schisandraceae Schisandra chinensis (Turcz.) Baill. Inflammation/Immunology Disease Research Fields Source Classification	COX
Macelignan ((+)-Anwulignan; Anwuligan)?is an orally active lignan isolated from Myristica fragrans. Macelignan possesses many pharmacological activities, including anti-inflammatory, anti-cancer, anti-diabetes, and neuroprotective activities .

HY-129566

Withanolide B	Neurological Disease Classification of Application Fields Metabolic Disease Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	ERK Wnt β-catenin RUNX
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-Y1314

Dimethyl sulfone 3 Publications Verification	Productos naturales Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Bacterial
Dimethyl sulfone (Methyl Sulfonyl Methane) is a metabolic product of endogenous methanethiol metabolism and intestinal bacterial metabolism. Dimethyl sulfone inhibits choriocapillary endothelial (CCE) cell proliferation, also has many biological effects, including antiinflammatory, antioxidant, and local anesthetic effects that could be neuroprotective .

HY-N7449

Neamine	Infection Cardiovascular Disease Classification of Application Fields Disease Research Fields	Antibiotic Bacterial
Neamine, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine is an anti-angiogenesis agent targeting angiogenin. Neamine has potent antibacterial, antitumor and neuroprotective activities .

HY-N2067

Vanillyl alcohol 1 Publications Verification p-(Hydroxymethyl)guaiacol	Structural Classification Monophenols Gastrodia elata Bl. Classification of Application Fields Orchidaceae Other Diseases Phenols Plants Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Bcl-2 Family
Vanillyl alcohol (p-(Hydroxymethyl)guaiacol) is an orally active phenolic alcohol. Vanillyl alcohol reduces ROS generation. suppresses Bax, increases Bcl-2. Vanillyl alcohol has anti-angiogenic, anti-inflammatory, anti-nociceptive and neuroprotective effects. Vanillyl alcohol is used as a flavoring agent in foods and beverages .

HY-N11849

Moracin N 2 Publications Verification	Phenols Polyphenols Morus alba L. Plants Moraceae Source Classification	Ferroptosis Glutathione Peroxidase
Moracin N is a ferroptosis inhibitor that can be isolated from mulberry leaf. Moracin N exerts neuroprotective activity through preventing from oxidative stress .

HY-Z0283

Benzamide 1 Publications Verification Benzenecarboxamide; Phenylamide	Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite PARP
Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-100786

DL-AP3 1 Publications Verification	Structural Classification Productos naturales Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite mGluR Phosphatase
DL-AP3 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect .

HY-N2180

(+)-Eudesmin (+)-Eudesmine	Neurological Disease Classification of Application Fields Magnoliaceae Lignans Phenylpropanoids Magnolia biondii Pamp. Plants Disease Research Fields Source Classification	PKC PKA p38 MAPK NO Synthase
Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furanoid lignin. Pinoresinol dimethyl ether can be isolated from Magnolia biondii. Pinoresinol dimethyl ether activates MAPK, PKC, and PKA upstream pathways and inhibits NO levels. Pinoresinol dimethyl ether has neuroprotective activity .

HY-122267

Clovamide trans-Clovamide	Alkaloids other families Other Alkaloids Phenols Polyphenols Plants Source Classification	Reactive Oxygen Species (ROS) Bacterial Influenza Virus Apoptosis
Clovamide (trans-Clovamide), a natural phenolic compound, is a potent antioxidant. Clovamide is an excellent ROS and oxygen radical scavenger. Clovamide also has anti-inflammatory and neuroprotective effects . Clovamide is an anti-microbial with activity against the human pathogens influenza A subtype H5N1, *Trypanosoma evansi, and Heliobacter pylori* .

HY-126562

Piperlonguminine 1 Publications Verification	Infection Cardiovascular Disease Alkaloids Capsicum annuum L. Neurological Disease Classification of Application Fields Plants Solanaceae Inflammation/Immunology Disease Research Fields Source Classification	Bacterial Fungal Antibiotic
Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows various biological properties, including anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities .

HY-N9690

Longistyline A Longistylin A	Monophenols Leguminosae Phenols Plants Cajanus cajan (L.) Millsp.	Bacterial
Longistyline A (Longistylin A) is a natural stilbene, it can be isolated from leaves of Cajanus cajan. Longistyline A shows antimicrobial activity against MRSA with an MIC value of 1.56 μg/mL. Longistyline A shows neuroprotective effects, it can be used for the research of infection and nerve diseases .

HY-W748591

Cannflavin A	Flavonoids Cannabis sativa L Flavones Plants Moraceae Source Classification	Apoptosis Amyloid-β KMO
Cannflavin A can be isolated from Cannabis sativa L.. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ_1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO) (IC₅₀ = 29.4 μM). Cannflavin A activates apoptosis via caspase-3 cleavage. Cannflavin A exerts anti-inflammatory effects by inhibiting pro-inflammatory enzymes, including prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line .

HY-N14039

Pinus pinaster bark extract	Productos naturales Pinaceae Pinus pinaster. Plants Source Classification	Toll-like Receptor (TLR) Interleukin Related
Pinus pinaster bark extract is extracted from the bark of pine bark with antioxidant, anti-inflammatory and neuroprotective effects. Pinus pinaster bark extract increases toll-like receptor (TLR) activity, inducing production of IL-10 .

HY-N7335

Dehydroglyasperin C	Flavonoids Neurological Disease Classification of Application Fields Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Isoflavones Source Classification	Quinone Reductase Others
Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities .

HY-N0746

Oxysophocarpine 5+ Cited Publications	Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Sophora alopecuroides L Plants Disease Research Fields Source Classification Cancer	Others
Oxysophocarpine is an alkaloid extracted from Sophora alopecuroides.?Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems . Oxysophocarpine inhibits the?growth?and?metastasis?of ?oral?squamous?cell?carcinoma?(OSCC) .

HY-N3243

Moracin P 2 Publications Verification	other families Neurological Disease Classification of Application Fields Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS)
Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin P reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin P has neuroprotective and anti-inflammatory effects .

HY-N3883

Euxanthone	Flavonoids Garcinia oblongifolia Champ. ex Benth. Guttiferae Plants Other Flavonoids Source Classification	Autophagy
Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities .

HY-N1179

Tanshinone IIB	Cardiovascular Disease Quinones Structural Classification Neurological Disease Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Plants Naphthalene Quinones Disease Research Fields Source Classification	Apoptosis
Tanshinone IIB is a major active constituent of the roots of Salvia miltiorrhiza (Danshen) widely used for the research of stroke and coronary heart disease in Asian countries. Tanshinone IIB has a neuroprotective effect via inhibition of apoptosis .

HY-N4005

Isoastilbin	Flavanonols Flavonoids other families Phenols Polyphenols Plants Source Classification	Bacterial Tyrosinase
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC₅₀ value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .

HY-15121R

L-Theanine (Standard) L-Glutamic Acid γ-ethyl amide (Standard); Nγ-Ethyl-L-glutamine (Standard)	Structural Classification Microorganisms Amino acids Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Reference Standards Apoptosis Endogenous Metabolite Reactive Oxygen Species (ROS)
L-Theanine (Standard) is the analytical standard of L-Theanine. This product is intended for research and analytical applications. L-Theanine (L-Glutamic Acid γ-ethyl amide) is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective, anticancer and anti-oxidative activities. L-Theanine can pass through the blood–brain barrier and is orally active .

HY-N6880A

(-)-Rabdosiin	Structural Classification Ketones, Aldehydes, Acids Phenols Polyphenols Symphytum officinale L. Plants Boraginaceae	HIV
(-)-Rabdosiin is a novel phenolic marker, found from Symphytum officinale L. (-)-Rabdosiin shows antioxidant, neuroprotective or anti-HIV activities .

HY-N0037R

Albiflorin (Standard)	Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Plants Paeoniaceae Source Classification	Reference Standards Reactive Oxygen Species (ROS)
Albiflorin (Standard) is the analytical standard of Albiflorin. This product is intended for research and analytical applications. Albiflorin, a major constituent contained in peony root, is a monoterpene glycoside with neuroprotective effects. Albiflorin also has anti-inflammatory, antioxidant and antinociceptive effects .

HY-113631

Amorfrutin B	Monophenols Leguminosae Phenols Amorpha fruticosaL. Plants Source Classification	PPAR
Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with K_i values of 19 nM and EC₅₀ values of 73 nM, respectively. Amorfrutin B has hypoglycemic and neuroprotective activities .

HY-59208

4-Quinolinol Kynurine	Alkaloids Neurological Disease Classification of Application Fields Quinoline Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
4-Quinolone (Kynurine) is a quinoline derivative. Kynurine pathway modulates tryptophan metabolism and involves in neuroprotective effect. Kynurine promotes tumor cell survival and motility by suppressing antitumor immune .

HY-N7560R

Safranal (Standard)	Structural Classification Ketones, Aldehydes, Acids Lridaceae Plants Crocus sativus L. Source Classification	Keap1-Nrf2 Reference Standards
Safranal (Standard) is an analytical standard for Safranal. This product is intended for research and analytical applications. Safranal is the main component of saffron (Crocus sativus), is orally active, and is the source of the spice's unique aroma. Safranal has neuroprotective and anti-inflammatory effects and has research potential for Parkinson's disease.

HY-N0418R

Quercitrin (Standard) Quercetin 3-rhamnoside (Standard)	Flavonols Structural Classification Human Gut Microbiota Metabolites Flavonoids Microorganisms Phenols Polyphenols Erythrina stricta Roxb. Plants Compositae Endogenous metabolite Source Classification	Reference Standards Ribosomal S6 Kinase (RSK) Apoptosis Autophagy Reactive Oxygen Species (ROS)
Quercitrin (Standard) is the analytical standard of Quercitrin. This product is intended for research and analytical applications. Quercitrin (Quercetin 3-rhamnoside) is a bioflavonoid compound with potential anti-inflammation, antioxidative and neuroprotective effect. Quercitrin induces apoptosis of colon cancer cells. Quercitrin can be used for the research of cardiovascular and neurological disease research .

Cat. No.	Nom du produit	Chemical Structure

HY-B1773AS3

Sodium propionate-13C3

Sodium propionate- ¹³C-3 is the ¹³C-labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-N0092S2

Inosine-13C5 2 Publications Verification
Inosine- ¹³C₅ is the ¹³C₅ labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-113468AS

3-O-Methyldopa-d3

3-O-Methyldopa-d₃ (3-Methoxy-L-tyrosine-d₃) is deuterium labeled 3-O-Methyldopa (HY-113468A). 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease .

HY-15121S

L-Theanine-d5
L-Theanine-d₅ is the deuterium labeled L-Theanine. L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake .

HY-103252S

Monomethyl fumarate-d3 1 Publications Verification
Monomethyl fumarate-d₃ is a deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

HY-N0092S

Inosine-2,8-d2
Inosine-2,8-d₂ is the deuterium labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors .

HY-Y1055S3

Guanine-15N5
Guanine- ¹⁵N₅ is ¹⁵N labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-Y1055S

Guanine-13C
Guanine- ¹³C is the ¹³C labeled Guanine (HY-Y1055) . Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-B0220S2

Erythromycin-d3

Erythromycin-d₃ is the deuterium labeled Erythromycin . Erythromycin is a macrolide antibiotic produced by actinomycete Streptomyces erythreus with a broad spectrum of antimicrobial activity. Erythromycin binds to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin also exhibits antitumor and neuroprotective effect in different fields of research .

HY-B1899S

Taurodeoxycholic acid-d5

Taurodeoxycholic acid-d₅ is the deuterium labeled Taurodeoxycholic acid (HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .

HY-N0573S

Umbelliferone-d5

Umbelliferone-d₅ (7-Hydroxycoumarin-d₅) is the deuterium labeled Umbelliferone (HY-N0573 ). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

HY-B1773AS4

Sodium propionate-d5

Sodium propionate-d₅ is the deuterium labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-B1773AS

Sodium propionate-13C

Sodium propionate- ¹³C is the ¹³C labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-B0034S

Donepezil-d5 hydrochloride
Donepezil-d₅ (hydrochloride) is deuterium labeled Donepezil (Hydrochloride). Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-152052S

Linalool-d5

Linalool-d₅ is the deuterium labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-Y1055S1

Guanine-13C,15N2

Guanine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Guanine (HY-Y1055) . Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-17412AS

Minocycline-d6

Minocycline-d₆ is deuterium labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-15121S1

L-Theanine-13C2,15N2

L-Theanine- ¹³C₂, ¹⁵N₂ (L-Glutamic Acid γ-ethyl amide- ¹³C₂, ¹⁵N₂) is the ¹³C- and ¹⁵N-labeled L-Theanine (HY-15121). L-Theanine (L-Glutamic Acid γ-ethyl amide) is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective, anticancer and anti-oxidative activities. L-Theanine can pass through the blood–brain barrier and is orally active.

HY-103252S2

Monomethyl fumarate-d2
Monomethyl fumarate-d₂ is a deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

HY-B0034S1

Donepezil-d4 hydrochloride
Donepezil-d₄ (hydrochloride) is the deuterium labeled Donepezil hydrochloride. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-B0094S

Artemisinin-d3

Artemisinin-d₃ is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .

HY-128853S

Taurodeoxycholate-d6 sodium

Taurodeoxycholate-d₆ sodium salt is a bile salt-related anionic detergent. Taurodeoxycholate-d₆ sodium salt is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholate-d₆ sodium salt is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate-d₆ (TDCA) exhibits anti-inflammatory and neuroprotective effects .

HY-44178S

Diethyl butylmalonate-D9

Diethyl butylmalonate-d₉ is the deuterium labeled Diethyl butylmalonate (HY-44178). Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log(IGC₅₀ ^-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease .

HY-70057S1

Safinamide-d4-1

Safinamide-d₄-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.098 μM) over MAO-A (IC₅₀=580 μM) . Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC₅₀=8?μM) than at resting (IC₅₀=262?μM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al .

HY-B1773AS5

Sodium propionate-d3

Sodium propionate-d₃ is the deuterium labeled Propionate sodium (HY-B1773A). Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease .

HY-N0092S4

Inosine-13C3
Inosine-13C3 is a ¹³C-labeled Inosine that can be used in pharmacokinetic studies of Inosine. Inosine is an agonist of adenosine receptors A₁R and A_2AR with anti-inflammatory immunomodulatory, antinociceptive and neuroprotective effects .

HY-N0092S1

Inosine-13C
Inosine- ¹³C is the ¹³C labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-W754114

Nalmefene Sulfate-d3
Nalmefene Sulfate-d₃ is the deuterium labeled Nalmefene (HY-107744). Nalmefene is a BBB-penetrable opioid receptor modulator. Nalmefene is an antagonist of MOR and DOR, and a partial agonist of KOR. Nalmefene has anti-inflammatory and neuroprotective activities. Nalmefene can be used in the research of reducing alcohol-dependent disorders .

HY-14914S1

Azilsartan-d4
Azilsartan-d₄ is the deuterium labeled Azilsartan . Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research .

HY-117727S

Leriglitazone-d4

Leriglitazone-d₄ (MIN-102-d₄; Hydroxypioglitazone-d₄) is deuterium labeled Leriglitazone. Leriglitazone is an orally active and a BBB-penetrable PPARγ agonist with an EC₅₀ of 9 μM. Leriglitazone, as a regulator of mitochondrial function, has neuroprotective, anti-inflammatory and antioxidant effects. Leriglitazone can be used in the study of neuroinflammatory and neurodegenerative diseases .

HY-N0368S1

Linalool-13C3

Linalool- ¹³C₃ is ¹³C labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-B1490AS

Imipramine-d6

Imipramine-d₆ is the deuterium labeled Imipramine hydrochloride. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-N0055S

Chlorogenic acid-13C3

Chlorogenic acid- ¹³C₃ (Heriguard- ¹³C₃; NSC-407296- ¹³C₃) is ¹³C- and ¹⁵N-labeled Chlorogenic acid (HY-N0055). Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb.. It plays several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension .

HY-W777809

Guanine-13C2,15N

Guanine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-W711852

Benzamide-d5

Benzamide-d₅ (Benzenecarboxamide-d₅) is deuterium labeled Benzamide. Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-B1490S1

Imipramine-d3 hydrochloride

Imipramine-d₃ (hydrochloride) is deuterium labeled Imipramine (hydrochloride). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-128741S

D-Allose-13C

D-Allose- ¹³C is the ¹³C labeled D-Allose (HY-128741). D-Allose exhibits antitumor activity against various cancer cells. D-Allose scavenges reactive oxygen species (ROS) and reduces oxidative stress damage. D-Allose exhibits anti-inflammatory and neuroprotective through inhibition of TLR4/PI3K/AKT signaling pathway. D-Allose exhibits antihypertensive, cryoprotective, and anti-osteoporotic activities .

HY-W707863

Lercanidipine-d3

Lercanidipine-d₃ is the deuterium labeled Lercanidipine (HY-B0612). Lercanidipine is a third-generation, lipophilic, brain-penetrant, vascular-selective and orally active dihydropyridine-calcium channel blocker with a pIC₅₀ of 7.74 (converts from μM). Lercanidipine has long lasting antihypertensive action as well as reno- and neuro-protective effect. Lercanidipine also shows anti-oxidant, anti-inflammatory and anti-apoptotic properties. Lercanidipine can be used in cardiovascular and neurological research .

HY-17412S1

Minocycline-d6 sulfate

Minocycline-d₆ sulfate is deuterated labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-17412S

Minocycline-d6 hydrochloride

Minocycline-d₆ hydrochloride is deuterated labeled Minocycline hydrochloride (HY-17412). Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-B0144AS3

Pitavastatin-d4-1 sodium

Pitavastatin-d₄-1 (NK-104-d₄-1) sodium is the deuterium labeled Pitavastatin sodium (HY-B0144B). Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-W011978S

N-Acetyl-L-tryptophan-d3

N-Acetyl-L-tryptophan-d₃ is the deuterium labeled N-Acetyl-L-tryptophan (HY-W011978). N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-109502S

10-OH-NBP-d4
10-OH-NBP-d₄ is deuterium labeled 10-OH-NBP. 10-OH-NBP is a Butylphthalide (3-n-Butylphthalide; NBP; HY-B0647) hydroxylated metabolite and can penetrates the blood-brain barrier (BBB). Butylphthalide exerts neuroprotective effects and has potential for cerebral ischemia research .

HY-B1028S

Pantethine-15N2

Pantethine- ¹⁵N₂ is the ¹⁵N₂ labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

HY-B1490AS3

Imipramine-d4-1

Imipramine-d4-1 is the deuterium labeled Imipramine (HY-W010179). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-B0233S2

Isradipine-d7
Isradipine-d₇ is deuterated labeled Isradipine (HY-B0233). Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-17387S1

(-)-Huperzine A-d4 hydrochloride

(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

HY-W010410S

Oct-1-en-3-ol-d3

Oct-1-en-3-ol-d₃ is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-W010201S

Citronellol-d6

Citronellol-d₆ is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis ^.

HY-N1318S

Salvigenin-d9
Salvigenin-d₉ is the deuterium labeled Salvigenin. Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties .

Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-N0390G

L-Glutamine	mTOR NF-κB STAT HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
L-Glutamine GMP is L-Glutamine (HY-N0390) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na ⁺-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity .

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