Urocortin II, human
Based on 1 Customer Validation
Urocortin II, human is a selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor. Urocortin II, human has an effect of promoting satiet and neuroprotective effect. Urocortin II, human also has bactericidal, antiparasitic and pro-inflammation activity. Urocortin II, human can activate NF-κB pathway and ERK1/2 MAP kinase. Urocortin II, human can reduce pulmonary arterial hypertension and shows cardiac protection effect. Urocortin II, human can be used for the researches of infection, inflammation, metabolic, neurological and cardiovascular disease.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 351999-18-3
- Formula: C183H324N58O51
- Molecular Weight:4152.89
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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CRFR2 |
ERK1 |
ERK2 |
NF-κB |
Urocortin II, human shows bactericidal activity against E. coli, P. pseudoalcaligenes and M. luteus with EC50 values of 2.81, 1.16 and 4.92 μM[3].
Urocortin II, human shows antiparasitic activity against L. major, L. tropica and L. infantum with EC50 values of 9.20, 22.41 and 12.47 μM[3].
Urocortin II, human (0.1-1000 nM, 6-24 h) induces IL-8 mRNA and protein expression, activates the NF-κB pathway (IkBα degradation, p65 phosphorylation) and ERK1/2 MAP kinase in human colonic epithelial NCM460 cells overexpressing CRHR2α[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Urocortin II, human (2.5 μg/kg; i.p.; single dose) shows neuroprotective effect in intracerebral hemorrhage of rats[2].
Urocortin II, human (1 nM/mouse, i.p., administered at 1, 12, and 24 h after cecal ligation and puncture) improves survival rate, reduces bacterial load and inflammatory mediator levels in blood and peritoneal fluid, and alleviates tissue pathological damage in female BALB/c mouse models of sepsis[3].
Urocortin II, human (5 μg/kg, i.p., twice a day for 10 days) reduces pulmonary arterial hypertension, improves exercise capacity and attenuates pulmonary arterial and right ventricular remodelling and dysfunction in Monocrotaline (HY-0750)-induced rats[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICH rats induced by infusing bacterial collagenase VII[2]
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Dosage:2.5 μg/kg
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Administration:Intraperitoneally injection, single dose
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Result:Reduced modified Neurological Severity Scores from 8.4 on day 1 to 8.0 and 6.6 on days 3 and 7.
Chemical Information
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CAS No. 351999-18-3
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Appearance Solid
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Molecular Weight 4152.89
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Formula C183H324N58O51
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Color White to off-white
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Sequence
Ile-Val-Leu-Ser-Leu-Asp-Val-Pro-Ile-Gly-Leu-Leu-Gln-Ile-Leu-Leu-Glu-Gln-Ala-Arg-Ala-Arg-Ala-Ala-Arg-Glu-Gln-Ala-Thr-Thr-Asn-Ala-Arg-Ile-Leu-Ala-Arg-Val-NH2
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Sequence Shortening
IVLSLDVPIGLLQILLEQARARAAREQATTNARILARV-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 5 mg/mL (1.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (286 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Zorrilla EP,et al. Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity. J Pharmacol Exp Ther. 2004 Sep;310(3):1027-34. [Content Brief]
[2]. Liew HK, et al. Therapeutic effects of human urocortin-1, -2 and -3 in intracerebral hemorrhage of rats. Neuropeptides. 2015 Aug;52:89-96. [Content Brief]
[3]. Campos-Salinas J, et al. Protective role of the neuropeptide urocortin II against experimental sepsis and leishmaniasis by direct killing of pathogens. J Immunol. 2013 Dec 15;191(12):6040-51. [Content Brief]
[4]. Adão R, et al. Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension. [Content Brief]
[5]. Moss AC, et al. Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha. Gut. 2007 Sep;56(9):1210-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.2408 mL | 1.2040 mL | 2.4080 mL | 6.0199 mL |
Urocortin II, human Related Classifications
HY-P1752 Related Classifications
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