CB2 receptor agonist 6 

CB2 receptor agonist 6 (compound 70) is an agonist of CB2R, with EC₅₀ of 162 nM. The IC₅₀ values of CB2 receptor agonist 6 are 4.83 μM for CB1R and 0.88 μM for CB2R. CB2 receptor agonist 6 is a neuroprotective agent that can be used for the reseach of neurological disease^[1].

CB2 receptor agonist 6 (compound 70) (5 μM, 0/15/30/60 min) shows good metabolic stability in vitro ^[1].
CB2 receptor agonist 6 (5 μM, 0/0.5/1/1.5/2 h) can activate CB2R in vitro and inhibit cAMP expression in mice and humans^[1].
CB2 receptor agonist 6 (0.01-10 μM, 90 min) shows selectivity to CB2R , with the values of Ki are 8.8 nM for CB1R and 0.89 nM for CB2R^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CB2 receptor agonist 6 (compound 70) (1 mg/kg, intraperitoneal injection, predetermined intervals 0.25/0.5/1/2/6/24 h) can significantly reverse the forgetting effect of scopolamine-induced amnesia murine model, and does not affect the spatial learning and memory ability of naive mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

370.42

C₂₄H₁₉FN₂O

O=C(C1=CC=CN1CC2=CC=C(F)C=C2)NC3=CC(C4=CC=CC=C4)=CC=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Di Micco S, et al. Novel pyrrole based CB2 agonists: New insights on CB2 receptor role in regulating neurotransmitters' tone. Eur J Med Chem. 2024 Mar 11;269:116298.  [Content Brief]