CB2 receptor agonist 6
CB2 receptor agonist 6 (compound 70) is an agonist of CB2R, with EC50 of 162 nM. The IC50 values of CB2 receptor agonist 6 are 4.83 μM for CB1R and 0.88 μM for CB2R. CB2 receptor agonist 6 is a neuroprotective agent that can be used for the reseach of neurological disease.
For research use only. We do not sell to patients.
- Formula: C24H19FN2O
- Molecular Weight:370.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CB2R |
CB2 receptor agonist 6 (compound 70) (5 μM, 0/15/30/60 min) shows good metabolic stability in vitro [1].
CB2 receptor agonist 6 (5 μM, 0/0.5/1/1.5/2 h) can activate CB2R in vitro and inhibit cAMP expression in mice and humans[1].
CB2 receptor agonist 6 (0.01-10 μM, 90 min) shows selectivity to CB2R , with the values of Ki are 8.8 nM for CB1R and 0.89 nM for CB2R[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Scopolamine-induced amnesia murine model[1]
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Dosage:0.1 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg
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Administration:Subcutaneous injection (s.c.)
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Result:Showed neuroprotective effects on scopolamine induced cognitive function in male mice.
Did not affect spatial learning and memory processes in naïve mice.
Chemical Information
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Molecular Weight 370.42
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Formula C24H19FN2O
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SMILES
O=C(C1=CC=CN1CC2=CC=C(F)C=C2)NC3=CC(C4=CC=CC=C4)=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CB2 receptor agonist 6 Related Classifications
HY-163394 Related Classifications
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