2. Metabolic Enzyme/Protease Apoptosis NF-κB Immunology/Inflammation
  3. ACSL Family Endogenous Metabolite Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)
  4. 2-Phosphoglyceric acid

2-Phosphoglyceric acid  (Synonyms: DL-2-phosphoglyceric acid)

Cat. No.: HY-113167
Handling Instructions Technical Support

2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP). 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating ACSL4 and up-regulating GPX4, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell.

For research use only. We do not sell to patients.

2-Phosphoglyceric acid

2-Phosphoglyceric acid Chemical Structure

CAS No. : 2553-59-5

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2-Phosphoglyceric acid Related Antibodies

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GPX1 GPX4

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Description

2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP). 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating ACSL4 and up-regulating GPX4, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell[1][2][3].

IC50 & Target

ACSL4

 

Human Endogenous Metabolite

 

In Vitro

2-Phosphoglyceric acid is significantly increased during the stationary phase of glycolysis in Lactococcus lactis, serving as a metabolic marker for the transition of cells from a state of rapid growth and active glycolysis to growth arrest or slow growth[1].
2-Phosphoglyceric acid (50-200 μM) is significantly downregulated in an oxygen-glucose deprivation/reperfusion (OGD/R)-induced injury model of mouse hippocampal neuronal cells (HT-22), and exogenous supplementation of this metabolite can effectively alleviate OGD/R-induced neuronal death[2].
2-Phosphoglyceric acid (100-200 μM) reduces intracellular Fe²⁺ accumulation and reactive oxygen species (ROS) levels in HT-22 cells, improves mitochondrial function, downregulates the expression of acyl-CoA synthetase long-chain family member 4 (ACSL4), and upregulates the expression of glutathione peroxidase 4 (GPX4) protein[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Phosphoglyceric acid Related Antibodies
In Vivo

2-Phosphoglyceric acid (100-200 μM, intracerebroventricularly injection (i.c.v.), single dose) can effectively alleviate the brain tissue damage and neuronal loss caused by hypoxic-ischemic brain injury in newborn rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hypoxic-ischemic brain damage (HIBD) model established in neonatal rats[2]
Dosage: 100 and 200 μM
Administration: Intraventricular injection (i.c.v), single dose
Result: Significantly reduced the volume of cerebral infarction.
Significantly increased the number of surviving neurons in the cortex and hippocampus, and reduced neuronal damage.
Molecular Weight

186.06

Formula

C3H7O7P
CAS No.
SMILES

O=C(O)C(OP(O)(O)=O)CO
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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2-Phosphoglyceric acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Phosphoglyceric acid2553-59-5DL-2-phosphoglyceric acidACSL FamilyEndogenous MetaboliteFerroptosisGlutathione PeroxidaseReactive Oxygen Species (ROS)Hypoxic-ischemic brain damage (HIBD)Oxygen-glucose deprivation/reoxygenation (OGD/R)NeuroprotectionACSL4/GPX4 axisInhibitorinhibitorinhibit

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