2553-59-5
2553-59-5
Chemical Structure
2-Phosphoglyceric acid
Synonym(s): DL-2-phosphoglyceric acid
- CAS No.: 2553-59-5
- Formula:C3H7O7P
- Molecular Weight:186.06
IUPAC Name: 3-hydroxy-2-(phosphonooxy)propanoic acid
InChIKey: GXIURPTVHJPJLF-UHFFFAOYSA-N
SMILES: O=C(O)C(OP(O)(O)=O)CO
Biological Activity: 2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP). 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating ACSL4 and up-regulating GPX4, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell[1][2][3].
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2-Phosphoglyceric acid | 2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP). 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating ACSL4 and up-regulating GPX4, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell. | |||||||||||||||||||||
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References
- [1]. Ramos A, et al. Relationship between glycolysis and exopolysaccharide biosynthesis in Lactococcus lactis. Appl Environ Microbiol. 2001 Jan;67(1):33-41. [Content Brief]
- [2]. Chen H, et al. Metabolomics analysis revealed the neuroprotective role of 2-phosphoglyceric acid in hypoxic-ischemic brain damage through GPX4/ACSL4 axis regulation. Eur J Pharmacol. 2024 May 15;971:176539. [Content Brief]
- [3]. Huang CK, et al. ENO1 and Cancer. Mol Ther Oncolytics. 2022 Jan 3;24:288-298. [Content Brief]
