TAT-N15
TAT-N15 is a p55PIK inhibitor with remarkable anti-inflammatory activity and neuroprotective effects. TAT-N15 can significantly inhibit the activation of IL-6, IL-8, Akt, and NF-κB pathways, as well as suppress the protein expression of phosphorylated STAT3 and NF-κB. By inhibiting the activation of Akt, STAT3, and NF-κB pathways, TAT-N15 is used in research on acute conjunctivitis, allergic rhinitis, chronic obstructive pulmonary disease (COPD), and stroke.
For research use only. We do not sell to patients.
- CAS No.: 2415370-74-8
- Formula: C155H250N48O40S3
- Molecular Weight:3522.14
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Chemical Information
-
CAS No. 2415370-74-8
-
Molecular Weight 3522.14
-
Formula C155H250N48O40S3
-
Sequence
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Met-Met-Pro-Tyr-Ser-Thr-Glu-Leu-Ile-Phe-Tyr-Ile-Glu-Met-Asp-Pro
-
Sequence Shortening
YGRKKRRQRRRMMPYSTELIFYIEMDP
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Liu Y, et al. A novel p55PIK signaling peptide inhibitor alleviates neuroinflammation via the STAT3/NF-kB signaling pathway in experimental stroke[J]. Journal of Stroke and Cerebrovascular Diseases, 2024, 33(7): 107736. [Content Brief]
[2]. Wang T, et al. p55PIK deficiency and its NH2-terminal derivative inhibit inflammation and emphysema in COPD mouse model[J]. American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021, 321(1): L159-L173. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)