Tetramethylpyrazine nitrone
Tetramethylpyrazine nitrone is a nitrone derivative of tetramethylpyrazine. Tetramethylpyrazine nitrone is an active ingredient from Ligusticum wallichii Franchat. Tetramethylpyrazine nitrone is a potent scavenger of free radicals with neuroprotective activitys in both rat and monkey models of ischemis stroke. Tetramethylpyrazine nitrone can suppress over-expression of neuroinflammatory marker vimentin.
For research use only. We do not sell to patients.
- CAS No.: 1083171-75-8
- Formula: C12H19N3O
- Molecular Weight:221.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1083171-75-8
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Molecular Weight 221.30
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Formula C12H19N3O
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SMILES
CC1=C(C)N=C(C)C(/C=[N+](C(C)(C)C)\[O-])=N1
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Synonyms
TBN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhou, X., et al., (2023). Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer's disease mouse model and proteomics analysis. Frontiers in pharmacology, 14, 1082602. [Content Brief]
[2]. Zhang, Z., et al., (2016). Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy. Scientific reports, 6, 37148. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tetramethylpyrazine nitrone Related Classifications
HY-202233 Related Classifications
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