1083171-75-8
1083171-75-8
Chemical Structure
Tetramethylpyrazine nitrone
Synonym(s): TBN
- CAS No.: 1083171-75-8
- Formula:C12H19N3O
- Molecular Weight:221.30
InChIKey: BESRYENXPUCIID-CHHVJCJISA-N
SMILES: CC1=C(C)N=C(C)C(/C=[N+](C(C)(C)C)\[O-])=N1
Biological Activity: Tetramethylpyrazine nitrone is a nitrone derivative of tetramethylpyrazine. Tetramethylpyrazine nitrone is an active ingredient from Ligusticum wallichii Franchat. Tetramethylpyrazine nitrone is a potent scavenger of free radicals with neuroprotective activitys in both rat and monkey models of ischemis stroke. Tetramethylpyrazine nitrone can suppress over-expression of neuroinflammatory marker vimentin[1][2].
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Tetramethylpyrazine nitrone | Tetramethylpyrazine nitrone is a nitrone derivative of tetramethylpyrazine. Tetramethylpyrazine nitrone is an active ingredient from Ligusticum wallichii Franchat. Tetramethylpyrazine nitrone is a potent scavenger of free radicals with neuroprotective activitys in both rat and monkey models of ischemis stroke. Tetramethylpyrazine nitrone can suppress over-expression of neuroinflammatory marker vimentin. | |||||||||||||||||||||
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References
- [1]. Zhou, X., et al., (2023). Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer's disease mouse model and proteomics analysis. Frontiers in pharmacology, 14, 1082602. [Content Brief]
- [2]. Zhang, Z., et al., (2016). Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy. Scientific reports, 6, 37148. [Content Brief]
