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  2. Prosaptide Tx14(A) TFA

Prosaptide Tx14(A) TFA 

Cat. No.: HY-P1342A
Handling Instructions

Prosaptide Tx14(A) TFA, a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.

For research use only. We do not sell to patients.

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Prosaptide Tx14(A) TFA Chemical Structure

Prosaptide Tx14(A) TFA Chemical Structure

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Description

Prosaptide Tx14(A) TFA, a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2].

In Vitro

Prosaptide Tx14(A) TFA promotes the endocytosis of GPR37 and GPR37L1, bound to both receptors and activated signaling in a GPR37- and GPR37L1-dependent manner. Prosaptide Tx14(A) TFA is the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also known as sulfated glycoprotein-1)[1].

Molecular Weight

1693.72

Formula

C₇₁H₁₁₁F₃N₁₆O₂₈

Sequence

Thr-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr

Sequence Shortening

TALIDNNATEEILY

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Prosaptide Tx14(A)OthersactivefragmentneuroprotectiveglioprotectivefactorprosaposinendocytosisphosphorylationInhibitorinhibitorinhibit

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Prosaptide Tx14(A) TFA
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HY-P1342A
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