7-Methoxy-4H-chromen-4-one-o-carborane 

7-Methoxy-4H-chromen-4-one-o-carborane is an ER agonist and COX inhibitor with a COX-1 IC₅₀ of 3.0 μM, COX-2 IC₅₀ of 1.0 μM. 7-Methoxy-4H-chromen-4-one-o-carborane can be used for research on antimicrobial, anti-inflammatory, antitumor, neuroprotective, and estrogenic effects^[1].

7-Methoxy-4H-chromen-4-one-o-carborane (Compound 2) potently inhibits purified COX-1 and COX-2 with IC₅₀s of 3.0 μM and 1.0 μM, respectively^[1].
7-Methoxy-4H-chromen-4-one-o-carborane (48 h) shows no antiproliferative activity against Raji, Ramos, PC3, and HepG2 cell lines^[1].
7-Methoxy-4H-chromen-4-one-o-carborane binds to COX-1 and COX-2 proteins with its chromone scaffold inserted into the protein pockets and carborane at the pocket entrance, and forms a hydrogen bond with COX-2 Tyr385 that contributes to its COX-2 selectivity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

318.38

C₁₂H₁₈B₁₀O₃

3097646-97-1

O=C1C2=CC=C(OC)C=C2OC=C1C3456[BH]789[BH]%10%11%12[BH]%13%14%15[BH]%10%169[BH]%13%17%18[BH]%14%19%20[BH]%15%11%21[BH]%1276[BH]%21%195[CH]%17%204[BH]%16%1883

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang Y, et al. Synthesis of Carborane-Containing Flavone and Flavonol Analogues as ER Agonists and COX Inhibitors. J Nat Prod. 2026;89(4):1189-1197.