2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS)
  4. Adaptaquin

Adaptaquin is a BBB-penetrable HIF-PHDs inhibitor. Adaptaquin has anti-inflammatory and neuroprotective effects. Adaptaquin can effectively inhibit lipid peroxidation, maintain mitochondrial function, and reduce neuronal death. Adaptaquin can be used in the research of nervous system diseases such as Parkinson's disease.

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Adaptaquin

Adaptaquin 構造式

CAS 番号 : 385786-48-1

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 在庫あり
Solution
10 mM * 1 mL in DMSO USD 66 在庫あり
Solid
5 mg $60 在庫あり
10 mg $100 在庫あり
25 mg $200 在庫あり
50 mg $320 在庫あり
100 mg $500 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 2 publication(s) in Google Scholar

Other Forms of Adaptaquin:

Adaptaquin 関連抗体

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HIF/HIF Prolyl-Hydroxylase アイソフォーム固有の製品をすべて表示:

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HIF-1α HIF

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製品説明

Adaptaquin is a BBB-penetrable HIF-PHDs inhibitor. Adaptaquin has anti-inflammatory and neuroprotective effects. Adaptaquin can effectively inhibit lipid peroxidation, maintain mitochondrial function, and reduce neuronal death. Adaptaquin can be used in the research of nervous system diseases such as Parkinson's disease[1][2][3].

体外実験

Adaptaquin (0.5-5 μM; 4-15 h) can increase the viability of glutamate-treated HT-22 cells and inhibit lipid peroxidation and ROS production[1].
Adaptaquin (0.1-5 μM; 24-48 h) can significantly protect PC12 cells and ventral midbrain dopaminergic neurons from cell death induced by Oxidopamine (HY-B1081) (6-OHDA) and MPP+ (HY-W008719) and maintain cell morphology[2].
Adaptaquin (0.5 μM; 8-16 h) can inhibit the expression of Trib3, ATF4, and CHOP induced by 6-OHDA/MPP+ and maintain the Parkin protein level in PC12 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Adaptaquin 関連抗体

Real Time qPCR[2]

Cell Line: 6-OHDA/ MPP+ treated PC12
Concentration: 0.5 μM
Incubation Time: 8 h/16 h
Result: Reduced the mRNA levels of Trib3, ATF4 and CHOP.
体内実験

Adaptaquin (30 mg/kg; intraperitoneal injection; 7 days) has a protective effect in a mouse model of Parkinson's disease[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male C57BL/6 mice (10-12 weeks) treated 6-OHDA hydrobromide (HY-B1081A)[2]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; 7 days
Result: Enhanced survival of dopaminergic neurons and substantially protected their striatal projections.
Significantly enhanced retention of nigrostriatal function.
分子量

377.82

分子式

C21H16ClN3O2
CAS 番号
Appearance

Solid

Color

White to yellow

SMILES

OC1=C2N=CC=CC2=CC=C1C(C3=CC=C(Cl)C=C3)NC4=NC=CC=C4O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (264.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6468 mL 13.2338 mL 26.4676 mL
5 mM 0.5294 mL 2.6468 mL 5.2935 mL
10 mM 0.2647 mL 1.3234 mL 2.6468 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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純度とドキュメンテーション

純度: 99.87%

COA (254 KB) HNMR (270 KB) LCMS (95 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6468 mL 13.2338 mL 26.4676 mL 66.1691 mL
5 mM 0.5294 mL 2.6468 mL 5.2935 mL 13.2338 mL
10 mM 0.2647 mL 1.3234 mL 2.6468 mL 6.6169 mL
15 mM 0.1765 mL 0.8823 mL 1.7645 mL 4.4113 mL
20 mM 0.1323 mL 0.6617 mL 1.3234 mL 3.3085 mL
25 mM 0.1059 mL 0.5294 mL 1.0587 mL 2.6468 mL
30 mM 0.0882 mL 0.4411 mL 0.8823 mL 2.2056 mL
40 mM 0.0662 mL 0.3308 mL 0.6617 mL 1.6542 mL
50 mM 0.0529 mL 0.2647 mL 0.5294 mL 1.3234 mL
60 mM 0.0441 mL 0.2206 mL 0.4411 mL 1.1028 mL
80 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8271 mL
100 mM 0.0265 mL 0.1323 mL 0.2647 mL 0.6617 mL
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Adaptaquin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adaptaquin385786-48-1HIF/HIF Prolyl-HydroxylaseReactive Oxygen Species (ROS)Hypoxia-inducible factorsHIFsHIF-PHHT-22PC12VM DA neuronsPD modelInhibitorinhibitorinhibit

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製品名:
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製品番号:
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