2. Adaptaquin

Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PHD2), with an IC50 of 2 μM. Adaptaquin can inhibit lipid peroxidation and maintain mitochondrial function.

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Adaptaquin Chemical Structure

Adaptaquin Chemical Structure

CAS No. : 385786-48-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid
5 mg USD 60 In-stock
10 mg USD 100 In-stock
25 mg USD 200 In-stock
50 mg USD 320 In-stock
100 mg USD 500 In-stock
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Based on 1 publication(s) in Google Scholar

Adaptaquin Related Antibodies

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1 Publications Citing Use of MCE Adaptaquin

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Description

Adaptaquin is an inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PHD2), with an IC50 of 2 μM. Adaptaquin can inhibit lipid peroxidation and maintain mitochondrial function[1][2].

IC50 & Target

IC50: 2 μM (HIF-PHD2)[1]
Molecular Weight

377.82

Formula

C21H16ClN3O2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

OC1=C2N=CC=CC2=CC=C1C(C3=CC=C(Cl)C=C3)NC4=NC=CC=C4O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (264.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6468 mL 13.2338 mL 26.4676 mL
5 mM 0.5294 mL 2.6468 mL 5.2935 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6468 mL 13.2338 mL 26.4676 mL 66.1691 mL
5 mM 0.5294 mL 2.6468 mL 5.2935 mL 13.2338 mL
10 mM 0.2647 mL 1.3234 mL 2.6468 mL 6.6169 mL
15 mM 0.1765 mL 0.8823 mL 1.7645 mL 4.4113 mL
20 mM 0.1323 mL 0.6617 mL 1.3234 mL 3.3085 mL
25 mM 0.1059 mL 0.5294 mL 1.0587 mL 2.6468 mL
30 mM 0.0882 mL 0.4411 mL 0.8823 mL 2.2056 mL
40 mM 0.0662 mL 0.3308 mL 0.6617 mL 1.6542 mL
50 mM 0.0529 mL 0.2647 mL 0.5294 mL 1.3234 mL
60 mM 0.0441 mL 0.2206 mL 0.4411 mL 1.1028 mL
80 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.8271 mL
100 mM 0.0265 mL 0.1323 mL 0.2647 mL 0.6617 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adaptaquin385786-48-1Inhibitorinhibitorinhibit

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