country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-152472

Copy Link Print Information

ENT-C225

Customer Review

Based on 1 Customer Validation

ENT-C225 is an effective activator of TrkB neurotrophin receptor. ENT-C225 has high effect on activating TrkB receptor (TrkBR), and has good physicochemical properties and neuroprotective properties.

For research use only. We do not sell to patients.

Purity: 99.16%
CAS No.: 2919962-53-9
Formula: C₂₆H₄₀N₄O₅
Molecular Weight:488.62

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

ENT-C225 Chemical Structure

CAS No.: 2919962-53-9

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Trk Receptor Isoforms :

In Vitro

ENT-C225 (Compound 10) (1 µM; 24 h) significantly improves NIH-3T3 TrkB cytotoxicity and reduces cell mortality^[1].
ENT-C225 (1 µM; 20 min) promotes TrkB receptor phosphorylation in NIH-3T3 TrkB cells and primary astrocytes^[1].
ENT-C225 (500 pM-1 µM; 48 h) has significant neuroprotective effect and enhances in a dose-dependent manner. ENT-C225 promoting the accumulation of TAR DNA-binding protein 43 (TDP43) in the neural network and cytoplasm of spinal motor neurons^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2919962-53-9
Appearance Solid
Molecular Weight 488.62
Formula C₂₆H₄₀N₄O₅
Color White to off-white
SMILES

O=C(C1=CC(C(NCCO)=O)=CC(C(NCC2CCN(CC2)CC3CCCCC3)=O)=C1)NCCO
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Antonijevic M, et al. Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor. Eur J Med Chem. 2023 Feb 15;248:115111. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

ENT-C225

MCE Bioactive Compound Library

All Trk Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ENT-C225 Related Classifications

HY-152472 Related Classifications