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Cat. No.: HY-175823

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1,4-Naphthoquinone-NH-C2-NH-Trolox

1,4-Naphthoquinone-NH-C2-NH-Trolox is a brain-penetrant Trolox (HY-101445)-vitamin K (HY-B2172) conjugate with neuroprotective activity. 1,4-Naphthoquinone-NH-C2-NH-Trolox can inhibit oxytosis, ferroptosis, ATP depletion and ROS production. 1,4-Naphthoquinone-NH-C2-NH-Trolox selective suppresses M1 markers expression. 1,4-Naphthoquinone-NH-C2-NH-Trolox can be used for the research of neurological disease, such as Alzheimer’s disease (AD).

For research use only. We do not sell to patients.

Formula: C₂₆H₂₈N₂O₅
Molecular Weight:448.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

1,4-Naphthoquinone-NH-C2-NH-Trolox Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

1,4-Naphthoquinone-NH-C2-NH-Trolox (Compound 16e) exhibits potent and comparable radical scavenging activity with an EC₅₀ of 15.4 μM^[1].
1,4-Naphthoquinone-NH-C2-NH-Trolox (0.38-25 μM, 24 h) inhibit oxytosis, ferroptosis, and ATP depletion in HT22 hippocampal nerve cells^[1].
1,4-Naphthoquinone-NH-C2-NH-Trolox (0.4 μM, 8 h) reduces ROS production in HT22 cells^[1].
1,4-Naphthoquinone-NH-C2-NH-Trolox (0.5-2.5 μM, 24 h) selective suppresses M1 markers in HT22 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HT22 cells
Concentration:

0.5, 1 and 2.5 μM
Incubation Time:

24 h
Result:

Dose-dependently suppressed nitrite accumulation and IL-1β release.
Attenuated LPS-induced iNOS protein upregulation.
Did not modulate expression of the M2 markers TREM2 or TGFβ2.

In Vivo

1,4-Naphthoquinone-NH-C2-NH-Trolox (Compound 16e) (0.1 mg/kg, i.p., daily for 7 days) ameliorates Aβ_25-35 (HY-P0128)-induced cognitive deficits in AD mice modes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Aβ^25-35 (HY-P0128)-induced acuteAlzheimer’s disease (AD) mice models^[1]
Dosage:

0.1 mg/kg
Administration:

Intraperitoneally injection, daily for 7 days
Result:

Significantly ameliorated Aβ_25-35-induced working memory deficits.
Did not ameliorate Aβ_25-35-induced long-term memory deficits.

Chemical Information

Molecular Weight 448.51
Formula C₂₆H₂₈N₂O₅
SMILES

O=C(C1(C)CCC2=C(O1)C(C)=C(C)C(O)=C2C)NCCNC(C3=O)=CC(C4=C3C=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. He F, et al. Vitamin K-Trolox synergism realized in hybrid neuroprotectant with potent anti-ferroptosi/oxytosis activity, reduced toxicity, and in vivo efficacy in Alzheimer's disease mouse model. Eur J Med Chem. 2025 Dec 5;299:118068. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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