MRS4596
MRS4596 is a potent and selective P2X4 receptor antagonist with an IC50 value of 1.38 μM for human P2X4 receptor. MRS4596 has neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4596 can be used in research of ischemic stroke .
For research use only. We do not sell to patients.
- CAS No.: 2840581-38-4
- Formula: C22H15N4NaO3S
- Molecular Weight:438.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 1.38 μM (human P2X4 receptor)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female young C57B/6 mice (8-12 weeks; induced transient focal cerebral ischemia by a 60 min right middle cerebral artery occlusion)[1]
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Dosage:5 mg/kg
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Administration:3 days continuous infusion with an Alzet minipump
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Result:Decreased in total hemispheric infarct volume while effects were not significant on cortical or striatal infarct volume alone.
Chemical Information
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CAS No. 2840581-38-4
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Molecular Weight 438.43
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Formula C22H15N4NaO3S
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SMILES
O=C(C1)NC(C2=CC=C(C=C2C=C3)C)=C3N(C4=CC=CC(C([N-]5)=NOC5=S)=C4)C1=O.[Na+]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MRS4596 Related Classifications
HY-151546 Related Classifications
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