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Referencia número: HY-147939

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AChE/BuChE-IN-3

AChE/BuChE-IN-3 is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC₅₀s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ_1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 2742707-47-5
Fòrmula: C₃₀H₃₀F₃N₃O₆
Peso molecular:585.57

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AChE/BuChE-IN-3 Chemical Structure

No. CAS: 2742707-47-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
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Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

AChE

0.65 μM (IC₅₀)

BChE

5.77 μM (IC₅₀)

Ver todos los productos específicos de isoformas Cholinesterase (ChE) :

AChE
BChE

In Vitro

AChE/BuChE-IN-3 (compound C4) (12.5-100 μM; 48 hours) exhibits no cytotoxicity on the human neuroblastoma cell line SH-SY5Y, and slightly increases cell viabilities^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SH-SY5Y
Concentration:

12.5 μM, 25 μM, 50 μM and 100 μM
Incubation Time:

48 hours
Result:

Exhibited no cytotoxicity on the human neuroblastoma cell line SH-SY5Y, and slightly increased cell viabilities.

Chemical Information

No. CAS 2742707-47-5
Peso molecular 585.57
Fòrmula C₃₀H₃₀F₃N₃O₆
SMILES

FC(C1=CC=C(CN2N=NC(COC3=CC(OC)=C4CCC(C5=CC(OC)=C(OC)C(OC)=C5)OC4=C3)=C2)C=C1)(F)F
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Shi S, et al. Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease. Bioorg Chem. 2020 Jul;100:103917. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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AChE/BuChE-IN-3

Ver todos los productos específicos de isoformas Cholinesterase (ChE)

Actividad biológica

Descripciòn

IC50 & Target

In Vitro

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

AChE/BuChE-IN-3 Related Classifications

HY-147939 Related Classifications

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