2742707-47-5
Chemical Structure
AChE/BuChE-IN-3
- CAS No.: 2742707-47-5
- Formula:C30H30F3N3O6
- Molecular Weight:585.57
IUPAC Name: 4-(((5-methoxy-2-(3,4,5-trimethoxyphenyl)chroman-7-yl)oxy)methyl)-1-(4-(trifluoromethyl)benzyl)-1H-1,2,3-triazole
InChIKey: VEELDJJRSMRMQE-UHFFFAOYSA-N
SMILES: FC(C1=CC=C(CN2N=NC(COC3=CC(OC)=C4CCC(C5=CC(OC)=C(OC)C(OC)=C5)OC4=C3)=C2)C=C1)(F)F
Biological Activity: AChE/BuChE-IN-3 is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC50s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease[1].
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AChE/BuChE-IN-3 | AChE/BuChE-IN-3 is a potent and blood-brain barrier (BBB) penetrant AChE and BuChE dual inhibitor with IC50s of 0.65 μM and 5.77 μM for AChE and BuChE. AChE/BuChE-IN-3 also inhibits Aβ1-42 aggregation. AChE/BuChE-IN-3 has effectively neuroprotective activities and nearly no toxicity on SH-SY5Y cells. AChE/BuChE-IN-3 can be used for researching Alzheimer's disease. | |||||||||||||||||||||
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Keywords
