1. Cell Cycle/DNA Damage
    Epigenetics
    Apoptosis
  2. HDAC
    Apoptosis
  3. MI-192

MI-192 

Cat. No.: HY-110264
Handling Instructions

MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities.

For research use only. We do not sell to patients.

MI-192 Chemical Structure

MI-192 Chemical Structure

CAS No. : 1415340-63-4

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Description

MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities[1][2].

In Vitro

MI-192 (0.15-1 μM; 72 h) induces differentiation and is cytotoxic through promotion of apoptosis in acute myeloid leukaemic cell lines U937, HL60 and Kasumi-1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: HL60 and Kasumi-1 cells
Concentration: 150 nM, 300 nM, 500 nM, 1 μM
Incubation Time: 72 h
Result: Induced a substantial degree of apoptosis in both HL60 and Kasumi-1 cells.
In Vivo

MI-192 (40 mg/kg; i.p; once a day; for 3 days) shows the neuroprotective activity in the mouse brain subjected to photothrombotic stroke[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male outbred mice CD-1 (20-25 g) with photothrombotic stroke (PTS)[2]
Dosage: 40 mg/kg
Administration: i.p; once a day; for 3 days
Result: Reduced the volume of the PTS-induced infarction core in the mouse brain, partly restored the functional symmetry in the forelimb use, decreased the level of PTS-induced apoptosis and acetylation of α-tubulin characteristic for stable microtubules, and increased the expression of GAP-43 in the cerebral cortex of the damaged hemisphere.
Molecular Weight

383.44

Formula

C₂₄H₂₁N₃O₂

CAS No.
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Storage

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MI-192
Cat. No.:
HY-110264
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