2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. MI-192

MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities.

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MI-192 Chemical Structure

MI-192 Chemical Structure

CAS No. : 1415340-63-4

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MI-192 Related Antibodies

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Description

MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities[1][2].

In Vitro

MI-192 (0.15-1 μM; 72 h) induces differentiation and is cytotoxic through promotion of apoptosis in acute myeloid leukaemic cell lines U937, HL60 and Kasumi-1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MI-192 Related Antibodies

Apoptosis Analysis[1]

Cell Line: HL60 and Kasumi-1 cells
Concentration: 150 nM, 300 nM, 500 nM, 1 μM
Incubation Time: 72 h
Result: Induced a substantial degree of apoptosis in both HL60 and Kasumi-1 cells.
In Vivo

MI-192 (40 mg/kg; i.p; once a day; for 3 days) shows the neuroprotective activity in the mouse brain subjected to photothrombotic stroke[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male outbred mice CD-1 (20-25 g) with photothrombotic stroke (PTS)[2]
Dosage: 40 mg/kg
Administration: i.p; once a day; for 3 days
Result: Reduced the volume of the PTS-induced infarction core in the mouse brain, partly restored the functional symmetry in the forelimb use, decreased the level of PTS-induced apoptosis and acetylation of α-tubulin characteristic for stable microtubules, and increased the expression of GAP-43 in the cerebral cortex of the damaged hemisphere.
Molecular Weight

383.44

Formula

C24H21N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC=CC=C2C(CN1CC3=CC=C(C(NC4=C(C=CC=C4)N)=O)C=C3)=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

COA (249 KB)

Handling Instructions (2659 KB)
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MI-192 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MI-1921415340-63-4MI192MI 192HDACApoptosisHistone deacetylasesAnticanerneuroprotectiveHDAC2HDAC3apoptosisα-tubulinInhibitorinhibitorinhibit

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