1415340-63-4
1415340-63-4
Chemical Structure
MI-192
- CAS No.: 1415340-63-4
- Formula:C24H21N3O2
- Molecular Weight:383.44
IUPAC Name: N-(2-aminophenyl)-4-((4-methylene-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)methyl)benzamide
InChIKey: GTLTXEIKQVWSRF-UHFFFAOYSA-N
SMILES: O=C1C2=CC=CC=C2C(CN1CC3=CC=C(C(NC4=C(C=CC=C4)N)=O)C=C3)=C
Biological Activity: MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MI-192 | 99.9% | MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities. | ||||||||||||||||||||
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References
- [1]. Marjorie Boissinot, et al. Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leuk Res. 2012 Oct;36(10):1304-10. [Content Brief]
- [2]. S V Demyanenko, et al. The Neuroprotective Effect of the HDAC2/3 Inhibitor MI192 on the Penumbra After Photothrombotic Stroke in the Mouse Brain. Mol Neurobiol. 2020 Jan;57(1):239-248. [Content Brief]
Keywords
