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Cat. No.: HY-157215

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HDAC-IN-66

HDAC-IN-66 (compound 2F) is a selective HDAC inhibitor and Pomalidomide (HY-10984) derivative that potently inhibits hematological tumor cells.

For research use only. We do not sell to patients.

CAS No.: 3055552-04-7
Formula: C₂₇H₂₃N₅O₅
Molecular Weight:497.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

HDAC-IN-66 Chemical Structure

CAS No.: 3055552-04-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

HDAC-IN-66 (compound 2F) is a selective HDAC inhibitor and Pomalidomide (HY-10984) derivative that potently inhibits hematological tumor cells^[1].

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	5.54 μM Compound: 2f	Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay	[PMID: 37995564]
RPMI-8226	IC₅₀	5.75 μM Compound: 2f	Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay	[PMID: 37995564]
RS4-11	IC₅₀	1.57 μM Compound: 2f	Antiproliferative activity against human RS4-11 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human RS4-11 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay	[PMID: 37995564]
U-266	IC₅₀	4.89 μM Compound: 2f	Antiproliferative activity against human U-266 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay Antiproliferative activity against human U-266 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay	[PMID: 37995564]

Chemical Information

CAS No. 3055552-04-7
Molecular Weight 497.50
Formula C₂₇H₂₃N₅O₅
SMILES

NC1=CC=CC=C1NC(C2=CC=C(CNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen D et al. Serendipitous discovery of Class I HDAC inhibitors from rational design of molecular glue degraders targeting HDAC. Eur J Med Chem. 2023 Nov 19;263:115926. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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HDAC-IN-66

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HDAC-IN-66 Related Classifications

HY-157215 Related Classifications