L-Theanine-d5
Based on 1 Customer Validation
L-Theanine-d5 is the deuterium labeled L-Theanine. L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake.
For research use only. We do not sell to patients.
- Purity: 99%
- CAS No.: 1217451-85-8
- Formula: C7H9D5N2O3
- Molecular Weight:179.23
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1217451-85-8
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Unlabeled Cas 3081-61-6
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Appearance Solid
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Molecular Weight 179.23
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Formula C7H9D5N2O3
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Color White to off-white
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SMILES
OC([C@@H](N)CCC(NC([2H])([2H])C([2H])([2H])[2H])=O)=O
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Synonyms
L-Glutamic Acid γ-ethyl amide-d5; Nγ-Ethyl-L-glutamine-d5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 150 mg/mL (836.91 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Vuong QV, et al. L-Theanine: properties, synthesis and isolation from tea. J Sci Food Agric. 2011 Aug 30;91(11):1931-9. [Content Brief]
[3]. Kimura K, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45. [Content Brief]
[4]. Takeshima M, et al. l-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes. J Clin Biochem Nutr. 2016 Sep;59(2):93-99. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.5794 mL | 27.8971 mL | 55.7942 mL | 139.4856 mL |
| 5 mM | 1.1159 mL | 5.5794 mL | 11.1588 mL | 27.8971 mL | |
| 10 mM | 0.5579 mL | 2.7897 mL | 5.5794 mL | 13.9486 mL | |
| 15 mM | 0.3720 mL | 1.8598 mL | 3.7196 mL | 9.2990 mL | |
| 20 mM | 0.2790 mL | 1.3949 mL | 2.7897 mL | 6.9743 mL | |
| 25 mM | 0.2232 mL | 1.1159 mL | 2.2318 mL | 5.5794 mL | |
| 30 mM | 0.1860 mL | 0.9299 mL | 1.8598 mL | 4.6495 mL | |
| 40 mM | 0.1395 mL | 0.6974 mL | 1.3949 mL | 3.4871 mL | |
| 50 mM | 0.1116 mL | 0.5579 mL | 1.1159 mL | 2.7897 mL | |
| 60 mM | 0.0930 mL | 0.4650 mL | 0.9299 mL | 2.3248 mL | |
| 80 mM | 0.0697 mL | 0.3487 mL | 0.6974 mL | 1.7436 mL | |
| 100 mM | 0.0558 mL | 0.2790 mL | 0.5579 mL | 1.3949 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Theanine-d5 Related Classifications
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