Nizofenone
Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke.
For research use only. We do not sell to patients.
- CAS No.: 54533-85-6
- Formula: C21H21ClN4O3
- Molecular Weight:412.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Nizofenone (1 and 10 μM) prolongs the action potential duration of guinea-pig papillary muscle and dog Purkinje fibers[3].
Nizofenone (30 μM) suppresses the spontaneous activity of dog Purkinje fibers and guinea-pigs S-A node[3].
Nizofenone (100 μM) decreases the contractile force of guinea-pig papillary muscle[3].
Nizofenone (10 μM) inhibits the peroxidative disintegration of mitochondria (in rat brain mitochondrial suspension)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Nizofenone (10 mg/kg i.p.) inhibits ischemia-induced glutamate increase and lactate increase in the hippocampus of rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with chronic restraint stress[1]
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Dosage:3, 9 mg/kg
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Administration:Intraperitoneal injection (i.p.), daily
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Result:Increased crossing frequencies of the open field test.
Increased in the activities of enzymatic SOD and CAT.
Chemical Information
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CAS No. 54533-85-6
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Molecular Weight 412.87
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Formula C21H21ClN4O3
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SMILES
O=C(C1=C(Cl)C=CC=C1)C2=CC([N+]([O-])=O)=CC=C2N3C=CN=C3CN(CC)CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yi Liu, et al. Protective effects of nizofenone administration on the cognitive impairments induced by chronic restraint stress in mice. Pharmacol Biochem Behav. 2013 Jan;103(3):474-80. [Content Brief]
[2]. Y Matsumoto, et al. Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. Eur J Pharmacol. 1994 Sep 1;262(1-2):157-61. [Content Brief]
[3]. Y Miura, et al. [Effects of nizofenone on the action potential of guinea-pig papillary muscle and S-A node and dog Purkinje fibers]. [Content Brief]
[4]. H Yasuda, et al. Cerebral protective effect and radical scavenging action. J Neurochem. 1981 Oct;37(4):934-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nizofenone Related Classifications
HY-119513 Related Classifications
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