54533-85-6
54533-85-6
Chemical Structure
Nizofenone
- CAS No.: 54533-85-6
- Formula:C21H21ClN4O3
- Molecular Weight:412.87
IUPAC Name: (2-chlorophenyl)(2-(2-((diethylamino)methyl)-1H-imidazol-1-yl)-5-nitrophenyl)methanone
InChIKey: WZGBZLHGOVJDET-UHFFFAOYSA-N
SMILES: O=C(C1=C(Cl)C=CC=C1)C2=CC([N+]([O-])=O)=CC=C2N3C=CN=C3CN(CC)CC
Biological Activity: Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke[1][2][3].
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Nizofenone | Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke. | |||||||||||||||||||||
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References
- [1]. Yi Liu, et al. Protective effects of nizofenone administration on the cognitive impairments induced by chronic restraint stress in mice. Pharmacol Biochem Behav. 2013 Jan;103(3):474-80. [Content Brief]
- [2]. Y Matsumoto, et al. Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. Eur J Pharmacol. 1994 Sep 1;262(1-2):157-61. [Content Brief]
- [3]. Y Miura, et al. [Effects of nizofenone on the action potential of guinea-pig papillary muscle and S-A node and dog Purkinje fibers]. [Content Brief]
Keywords
