1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
    mAChR
  3. Blarcamesine

Blarcamesine (Synonyms: AVex-73; AE-37)

Cat. No.: HY-105296
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Blarcamesine (AVex-73;AE-37) is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome.

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Blarcamesine Chemical Structure

Blarcamesine Chemical Structure

CAS No. : 195615-83-9

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Description

Blarcamesine (AVex-73;AE-37) is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome[1].

IC50 & Target

Sigma-1 receptor, muscarinic receptor[1]

In Vivo

Blarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration[1].
Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice[1].
Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response[1].
Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice[1].

Animal Model: Female Mecp2tm1.1Bird/J HET (C57 background) mice[1]
Dosage: 10 mg/kg, 30 mg/kg
Administration: Oral administration, daily, for 6.5 weeks
Result: Reverse the deficits observed in the HET animals.
Molecular Weight

281.39

Formula

C₁₉H₂₃NO

CAS No.

195615-83-9

SMILES

CN(C)CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC1

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Keywords:

BlarcamesineAVex-73AE-37AVex73AVex 73AE37AE 37Sigma ReceptormAChRMuscarinic acetylcholine receptorAlzheimer'sdiseaseRettsyndromeanticonvulsantanti-amnesicneuroprotectiveantidepressantInhibitorinhibitorinhibit

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Blarcamesine
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