1. Neuronal Signaling GPCR/G Protein
  2. Sigma Receptor mAChR
  3. Blarcamesine

Blarcamesine  (Synonyms: Anavex 2-73 free base)

Cat. No.: HY-105296
Handling Instructions

Blarcamesine (Anavex 2-73 free base) is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Blarcamesine hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Blarcamesine Chemical Structure

Blarcamesine Chemical Structure

CAS No. : 195615-83-9

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Top Publications Citing Use of Products

1 Publications Citing Use of MCE Blarcamesine

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Blarcamesine (Anavex 2-73 free base) is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome[1].

IC50 & Target

Sigma 1 Receptor

 

In Vivo

Blarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration[1].
Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice[1].
Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response[1].
Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Mecp2tm1.1Bird/J HET (C57 background) mice[1]
Dosage: 10 mg/kg, 30 mg/kg
Administration: Oral administration, daily, for 6.5 weeks
Result: Reverse the deficits observed in the HET animals.
Clinical Trial
Molecular Weight

281.39

Formula

C19H23NO

CAS No.
SMILES

CN(C)CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Blarcamesine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Blarcamesine
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