1. GPCR/G Protein
    Neuronal Signaling
  2. Sigma Receptor
  3. Blarcamesine hydrochloride

Blarcamesine hydrochloride (Synonyms: AVex-73 hydrochloride; AE-37 hydrochloride)

Cat. No.: HY-101864 Purity: 99.85%
Handling Instructions

Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist with an IC50 of 860 nM.

For research use only. We do not sell to patients.

Blarcamesine hydrochloride Chemical Structure

Blarcamesine hydrochloride Chemical Structure

CAS No. : 195615-84-0

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Based on 1 publication(s) in Google Scholar

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Description

Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist with an IC50 of 860 nM.

IC50 & Target

IC50: 860 nM (Sigma-1 Receptor)[1]

In Vivo

The pre-administration of Blarcamesine (ANAVEX2-73) leads to a dose-dependent attenuation of the scopolamine induced alternation deficit, significant at 1 and 3 mg/kg. The pre-treatment with Blarcamesine hydrochloride attenuates the impairments of step-through latency, dose dependently and significantly at doses higher than 0.3 mg/kg[1]. The Blarcamesine hydrochloride treatment dose-dependently blocks the recognition memory deficit, with a significant effect measured at 1 mg/kg. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Blarcamesine hydrochloride at 0.1 and 1 mg/kg dose. Seven days after injections, Blarcamesine hydrochloride attenuates the decrease in Ser9 phosphorylation induced by the peptide at 0.3 and 1 mg/kg. The Blarcamesine hydrochloride treatment dose-dependently prevents the Aβ25-35-induced increase in Aβ1-42 content, with a significant effect at the highest dose tested[2].

Clinical Trial
Molecular Weight

317.85

Formula

C₁₉H₂₄ClNO

CAS No.

195615-84-0

SMILES

CN(C)CC1CCOC1(C2=CC=CC=C2)C3=CC=CC=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (78.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1461 mL 15.7307 mL 31.4614 mL
5 mM 0.6292 mL 3.1461 mL 6.2923 mL
10 mM 0.3146 mL 1.5731 mL 3.1461 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[2]

Male mice aged 7-9 weeks and weighing 32±2 g are used. Drugs (including Blarcamesine hydrochloride) are brought up to each dose by dilution and injected in a volume of 100 μL/20 g body weight. Animals are used between days 1 and 9 after i.c.v. injections for behavioral testing or killed before biochemical measures[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

BlarcamesineAVex-73AE-37AVex73AVex 73AE37AE 37Sigma ReceptorInhibitorinhibitorinhibit

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Product name:
Blarcamesine hydrochloride
Cat. No.:
HY-101864
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