Fabomotizole hydrochloride
Based on 1 Customer Validation
Fabomotizole (CM346) hydrochloride is a compound with anxiolytic and neuroprotective activities. Fabomotizole (CM346) hydrochloride also has activity against Giardia lamblia and has the potential to inhibit giardiasis.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 173352-39-1
- Formula: C15H22ClN3O2S
- Molecular Weight:343.87
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 173352-39-1
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Appearance Solid
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Molecular Weight 343.87
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Formula C15H22ClN3O2S
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Color Light yellow to yellow
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SMILES
CCOC1=CC=C2C(N=C(SCCN3CCOCC3)N2)=C1.Cl
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Synonyms
CM346 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (290.81 mM; Need ultrasonic)
DMSO : ≥ 44 mg/mL (127.96 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (145.40 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.9081 mL | 14.5404 mL | 29.0808 mL | 72.7019 mL |
| 5 mM | 0.5816 mL | 2.9081 mL | 5.8162 mL | 14.5404 mL | |
| 10 mM | 0.2908 mL | 1.4540 mL | 2.9081 mL | 7.2702 mL | |
| 15 mM | 0.1939 mL | 0.9694 mL | 1.9387 mL | 4.8468 mL | |
| 20 mM | 0.1454 mL | 0.7270 mL | 1.4540 mL | 3.6351 mL | |
| 25 mM | 0.1163 mL | 0.5816 mL | 1.1632 mL | 2.9081 mL | |
| 30 mM | 0.0969 mL | 0.4847 mL | 0.9694 mL | 2.4234 mL | |
| 40 mM | 0.0727 mL | 0.3635 mL | 0.7270 mL | 1.8175 mL | |
| 50 mM | 0.0582 mL | 0.2908 mL | 0.5816 mL | 1.4540 mL | |
| 60 mM | 0.0485 mL | 0.2423 mL | 0.4847 mL | 1.2117 mL | |
| 80 mM | 0.0364 mL | 0.1818 mL | 0.3635 mL | 0.9088 mL | |
| 100 mM | 0.0291 mL | 0.1454 mL | 0.2908 mL | 0.7270 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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