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Fabomotizole hydrochloride  (Synonyms: CM346 hydrochloride)

Cat. No.: HY-14895A Purity: 99.95%
COA Handling Instructions

Fabomotizole hydrochloride (CM346 hydrochloride) is an anxiolytic agent. Fabomotizole hydrochloride produces anxiolytic and neuroprotective effects without any muscle relaxant actions.

For research use only. We do not sell to patients.

Fabomotizole hydrochloride Chemical Structure

Fabomotizole hydrochloride Chemical Structure

CAS No. : 173352-39-1

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 154 In-stock
10 mM * 1 mL in DMSO USD 154 In-stock
5 mg USD 140 In-stock
10 mg USD 230 In-stock
50 mg USD 800 In-stock
100 mg USD 1280 In-stock
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This product is a controlled substance and not for sale in your territory.

Other Forms of Fabomotizole hydrochloride:

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Fabomotizole hydrochloride (CM346 hydrochloride) is an anxiolytic agent. Fabomotizole hydrochloride produces anxiolytic and neuroprotective effects without any muscle relaxant actions.

In Vitro

Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







Light yellow to yellow




Room temperature in continental US; may vary elsewhere.


4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (290.81 mM; Need ultrasonic)

DMSO : ≥ 44 mg/mL (127.96 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9081 mL 14.5404 mL 29.0808 mL
5 mM 0.5816 mL 2.9081 mL 5.8162 mL
10 mM 0.2908 mL 1.4540 mL 2.9081 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (145.40 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
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Fabomotizole hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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